The Botanical Drug Substance Crofelemer as a Model System for Comparative Characterization of Complex Mixture Drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.07.012
Abstract: Crofelemer is a botanical polymeric proanthocyanidin that inhibits chloride channel activity and is used clinically for treating HIV-associated secretory diarrhea. Crofelemer lots may exhibit significant physicochemical variation due to the natural source of the raw… read more here.
Keywords: drug substance; crofelemer; drug; model ... See more keywords
Randomized Clinical Trial: Crofelemer Treatment in Women With Diarrhea-Predominant Irritable Bowel Syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Gastroenterology"
DOI: 10.14309/ctg.0000000000000110
Abstract: INTRODUCTION: Crofelemer, the active compound purified from latex of Croton lechleri, has been shown to improve HIV and traveler's diarrhea and improve pain in women with irritable bowel syndrome–diarrhea (IBS-D). This trial evaluated the effect… read more here.
Keywords: crofelemer; irritable bowel; abdominal pain; bowel syndrome ... See more keywords