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   Articles with "crohn disease" as a keyword



Certolizumab pegol for induction of remission in Crohn's disease

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recommendations! Published in 2017 at "Cochrane Database of Systematic Reviews"

DOI: 10.1002/14651858.cd012893

Abstract: BACKGROUND Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, and immune response modulation is the main treatment strategy to induce remission in active CD. Certolizumab pegol (CZP) is a tumor necrosis… read more here.

Keywords: week; response; remission; placebo ... See more keywords
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Interventions for the management of abdominal pain in Crohn's disease

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recommendations! Published in 2020 at "Cochrane Database of Systematic Reviews"

DOI: 10.1002/14651858.cd013531

Abstract: This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the efficacy and safety of interventions for managing abdominal pain in people with Crohn's disease. read more here.

Keywords: abdominal pain; interventions management; management abdominal; pain crohn ... See more keywords

Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14295

Abstract: Crohn’s disease (CD) is characterized by the chronic inflammation of the gastrointestinal tract. A dysbiotic microbiome and a defective immune system are linked to CD, where hydrogen sulfide (H2S) microbial producers positively correlate with the… read more here.

Keywords: structural analysis; atopobium parvulum; crohn disease; cysteine ... See more keywords

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

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recommendations! Published in 2025 at "British Journal of Clinical Pharmacology"

DOI: 10.1002/bcp.70019

Abstract: The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK)… read more here.

Keywords: crohn disease; enzymes transporters; drug; variability intestinal ... See more keywords

Differential Association Between Default Mode Network Connectivity and Attachment Styles in Healthy Individuals and Crohn's Disease Patients

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recommendations! Published in 2025 at "Brain and Behavior"

DOI: 10.1002/brb3.70620

Abstract: Crohn's disease (CD) is associated with psychological disorders and insecure attachment styles, potentially reflecting the long‐lasting disease effect. Although functional magnetic resonance imaging (fMRI) studies revealed differences in CD patients relative to HC, the brain… read more here.

Keywords: disease; differential association; crohn disease; association default ... See more keywords

Model-Informed Deep Q-Networks to Guide Infliximab Dosing in Pediatric Crohn's Disease.

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recommendations! Published in 2025 at "Clinical pharmacology and therapeutics"

DOI: 10.1002/cpt.70118

Abstract: Model‐informed precision dosing (MIPD) utilizes pharmacokinetic/pharmacodynamic (PK/PD) models to optimize drug therapy. However, conventional MIPD often requires manual simulation and regimen selection, which are time‐consuming and demand specialized expertise. Reinforcement learning (RL), in which an… read more here.

Keywords: informed deep; crohn disease; infliximab dosing; model informed ... See more keywords
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Vedolizumab in the treatment of Crohn's disease: A promising therapeutic approach

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recommendations! Published in 2024 at "Drug Development Research"

DOI: 10.1002/ddr.22220

Abstract: Crohn's disease (CD) is a chronic and debilitating inflammatory bowel disease that affects millions of individuals worldwide. Despite the availability of various treatment options, a significant number of patients do not achieve remission or experience… read more here.

Keywords: disease; treatment; crohn disease; therapeutic approach ... See more keywords

Imaging Mass Cytometry‐Based Immune Profiling of Human Peyer's Patches in Patients with Crohn's Disease

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recommendations! Published in 2025 at "European Journal of Immunology"

DOI: 10.1002/eji.70071

Abstract: Lymphoid follicles in the human gut are critical immune hubs, yet their role in Crohn's disease pathogenesis remains poorly understood. Here, we apply multiplexed imaging mass cytometry to spatially profile Peyer's patches and lymphoid follicles… read more here.

Keywords: disease; crohn disease; cell; imaging mass ... See more keywords
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Machine learning gene expression predicting model for ustekinumab response in patients with Crohn's disease

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recommendations! Published in 2021 at "Immunity"

DOI: 10.1002/iid3.506

Abstract: Recent studies reported the responses of ustekinumab (UST) for the treatment of Crohn's disease (CD) differ among patients, while the cause was unrevealed. The study aimed to develop a prediction model based on the gene… read more here.

Keywords: machine learning; response; model; learning gene ... See more keywords

Expression profiles of circular RNAs in colon biopsies from Crohn's disease patients by microarray analysis

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recommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"

DOI: 10.1002/jcla.23788

Abstract: Circular RNAs (circRNAs) are involved in various diseases and serve as biomarkers. The present study aimed to investigate unique expression profiles of circRNAs in colon tissues of Crohn's disease (CD) and search novel biomarkers for… read more here.

Keywords: circular rnas; expression profiles; analysis; colon ... See more keywords

MALT1 reflects inflammatory cytokines, disease activity, and its chronological change could estimate treatment response to infliximab in Crohn's disease patients

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recommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"

DOI: 10.1002/jcla.24650

Abstract: Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) mediates the immunity and inflammatory response in multiple ways to be intimately involved in the progression of autoimmune diseases. This study intended to explore the linkage of… read more here.

Keywords: disease patients; disease; crohn disease; disease activity ... See more keywords