Certolizumab pegol for induction of remission in Crohn's disease
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DOI: 10.1002/14651858.cd012893
Abstract: BACKGROUND Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, and immune response modulation is the main treatment strategy to induce remission in active CD. Certolizumab pegol (CZP) is a tumor necrosis… read more here.
Keywords: week; response; remission; placebo ... See more keywords
Interventions for the management of abdominal pain in Crohn's disease
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DOI: 10.1002/14651858.cd013531
Abstract: This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the efficacy and safety of interventions for managing abdominal pain in people with Crohn's disease. read more here.
Keywords: abdominal pain; interventions management; management abdominal; pain crohn ... See more keywords
Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14295
Abstract: Crohn’s disease (CD) is characterized by the chronic inflammation of the gastrointestinal tract. A dysbiotic microbiome and a defective immune system are linked to CD, where hydrogen sulfide (H2S) microbial producers positively correlate with the… read more here.
Keywords: structural analysis; atopobium parvulum; crohn disease; cysteine ... See more keywords
Machine learning gene expression predicting model for ustekinumab response in patients with Crohn's disease
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DOI: 10.1002/iid3.506
Abstract: Recent studies reported the responses of ustekinumab (UST) for the treatment of Crohn's disease (CD) differ among patients, while the cause was unrevealed. The study aimed to develop a prediction model based on the gene… read more here.
Keywords: machine learning; response; model; learning gene ... See more keywords
Expression profiles of circular RNAs in colon biopsies from Crohn's disease patients by microarray analysis
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DOI: 10.1002/jcla.23788
Abstract: Circular RNAs (circRNAs) are involved in various diseases and serve as biomarkers. The present study aimed to investigate unique expression profiles of circRNAs in colon tissues of Crohn's disease (CD) and search novel biomarkers for… read more here.
Keywords: circular rnas; expression profiles; analysis; colon ... See more keywords
MALT1 reflects inflammatory cytokines, disease activity, and its chronological change could estimate treatment response to infliximab in Crohn's disease patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24650
Abstract: Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) mediates the immunity and inflammatory response in multiple ways to be intimately involved in the progression of autoimmune diseases. This study intended to explore the linkage of… read more here.
Keywords: disease patients; disease; crohn disease; disease activity ... See more keywords
Adipose tissue‐derived mesenchymal stem cells' acellular product extracellular vesicles as a potential therapy for Crohn's disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30756
Abstract: The breakdown of gastrointestinal tract immune homeostasis leads to Crohn's disease (CD). Mesenchymal stem cells (MSCs) have demonstrated clinical efficacy in treating CD in clinical trials, but there is little known about the mechanism of… read more here.
Keywords: extracellular vesicles; crohn disease; adipose tissue; mesenchymal stem ... See more keywords
Dysbiosis of the stool DNA and RNA virome in Crohn's disease
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DOI: 10.1002/jmv.28573
Abstract: Pathogenesis of Crohn's disease (CD) relates to gut microbiome dysbiosis. However, less is known about the viral microbiome, consisting of bacteriophages and eukaryotic viruses, in CD. Here, we profiled the stool virome, viral functions, and… read more here.
Keywords: disease; dysbiosis; crohn disease; rna virome ... See more keywords
Crohn's Disease Activity Evaluation by Transabdominal Ultrasonography: Correlation with Double‐Balloon Endoscopy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.15645
Abstract: Transabdominal ultrasonography (US) has been reported as a useful tool for evaluating Crohn's disease (CD) activity. Endoscopic findings and Crohn's disease activity index (CDAI) are currently considered the gold standard for assessing CD activity. We… read more here.
Keywords: correlation double; transabdominal ultrasonography; disease activity; activity ... See more keywords
Usefulness of Intestinal Ultrasound to Detect Small Intestinal Stenosis in Patients With Crohn's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.16038
Abstract: Double balloon enteroscopy (DBE) with retrograde contrast is useful as a monitoring tool for small intestinal lesions in Crohn's disease (CD), but these are burdensome for patients. Intestinal ultrasound (IUS) can be used with ease… read more here.
Keywords: stenosis patients; intestinal ultrasound; crohn disease; small intestinal ... See more keywords
Diagnostic Value of Quantitative Contrast‐Enhanced Ultrasound in Comparison to Endoscopy in Children With Crohn's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.16044
Abstract: Quantitative contrast‐enhanced US (CEUS) provides objective evaluation of bowel wall perfusion and has been reported as a useful method for evaluating Crohn's disease (CD) activity in children. We tested its' diagnostic accuracy in comparison to… read more here.
Keywords: comparison endoscopy; disease; crohn disease; quantitative contrast ... See more keywords