Inverse In Vitro Selection Enables Comprehensive Analysis of Cross‐Chiral L‐Aptamer Interactions
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DOI: 10.1002/cbic.202200520
Abstract: Aptamers composed of mirror‐image L‐(deoxy)ribose nucleic acids, referred to as L‐aptamers, are a promising class of RNA‐binding reagents. Yet, the selectivity of cross‐chiral interactions between L‐aptamers and their RNA targets remain poorly characterized, limiting the… read more here.
Keywords: vitro selection; cross chiral; aptamer; inverse vitro ... See more keywords
Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c09233
Abstract: Informational macromolecules in biology are composed of subunits of a single handedness, d-nucleotides in nucleic acids and l-amino acids in proteins. Although this chiral uniformity may be expedient, it is not a chemical necessity, as… read more here.
Keywords: cross chiral; chiral rna; exponential amplification; rna ... See more keywords