Catalytic membrane reactor for Suzuki‐Miyaura C‐C cross‐coupling: Explanation for its high efficiency via modeling
Sign Up to like & getrecommendations! Published in 2017 at "Aiche Journal"
DOI: 10.1002/aic.15379
Abstract: A polymeric catalytic membrane was previously prepared that showed remarkable efficiency for Suzuki-Miyaura C-C cross-coupling in a flow-through configuration. A mathematic model was developed and fitted to the experimental data to understand the significant apparent… read more here.
Keywords: membrane reactor; miyaura cross; catalytic membrane; suzuki miyaura ... See more keywords
Microwave‐Promoted Metal‐Free α‐Alkylation of Ketones with Cycloalkanes through Cross‐Coupling of C(sp3)−H Bonds
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201700256
Abstract: A MWI-promoted α-alkylation of ketones by using cycloalkanes as the alkylating agents under metal-free conditions is presented. Mechanistically, this alkylation involves a TBP-initiated and MWI-assisted formation of the required cycloalkyl radical and the α-ketone carbon… read more here.
Keywords: coupling sp3; sp3 bonds; alkylation; metal free ... See more keywords
Hiyama cross‐coupling reaction using Pd(II) nanocatalyst immobilized on the surface of Fe3O4@SiO2
Sign Up to like & getrecommendations! Published in 2018 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.3978
Abstract: We report a simple process for the synthesis of Fe3O4@SiO2/APTMS (APTMS = 3-aminopropyltrimethoxysilane) core–shell nanocatalyst support. The new nanocatalyst was prepared by stabilization of Pd(cdha)2 (cdha = bis(2-chloro-3,4-dihydroxyacetophenone)) on the surface of the Fe3O4@SiO2/APTMS support. The structure and composition… read more here.
Keywords: surface fe3o4; fe3o4 sio2; sio2; hiyama cross ... See more keywords
Data Mining the C−C Cross‐Coupling Genome
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DOI: 10.1002/cctc.201900597
Abstract: The speed and precision of machine‐learning (ML) techniques in determining quantum chemical properties has resulted in a considerable computational speed up in comparison to traditional quantum chemical methods, and now allows a desired property of… read more here.
Keywords: quantum chemical; chemical properties; coupling genome; cross ... See more keywords
Enantioselective synthesis of (R)-Cinacalcet via cobalt-catalysed asymmetric Negishi cross-coupling.
Sign Up to like & getrecommendations! Published in 2019 at "Chirality"
DOI: 10.1002/chir.23085
Abstract: A novel enantioselective synthesis of (R)-cinacalcet with 99% enantiomeric excesses (ee) has been achieved. The main strategies of the approach include a gram-scale cobalt-catalysed asymmetric cross-coupling of racemic ester with arylzinc reagent, Hoffman-type rearrangement of… read more here.
Keywords: catalysed asymmetric; cobalt catalysed; synthesis cinacalcet; cross coupling ... See more keywords
Antitrypanosomatid Pharmacomodulation at Position 3 of the 8‐Nitroquinolin‐2(1H)‐one Scaffold Using Palladium‐Catalysed Cross‐Coupling Reactions
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DOI: 10.1002/cmdc.201800456
Abstract: An antikinetoplastid pharmacomodulation study at position 3 of the recently described hit molecule 3‐bromo‐8‐nitroquinolin‐2(1H)‐one was conducted. Twenty‐four derivatives were synthesised using the Suzuki–Miyaura cross‐coupling reaction and evaluated in vitro on both Leishmania infantum axenic amastigotes… read more here.
Keywords: cross coupling; position; antitrypanosomatid pharmacomodulation; nitroquinolin one ... See more keywords
Iron-Catalyzed C-O Bond Activation: Opportunity for Sustainable Catalysis.
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DOI: 10.1002/cssc.201701287
Abstract: Oxygen-based electrophiles have emerged as some of the most valuable cross-coupling partners in organic synthesis due to several major strategic and environmental benefits, such as abundance and potential to avoid toxic halide waste. In this… read more here.
Keywords: iron catalyzed; catalysis; cross; activation ... See more keywords
Electrochemical Oxidative C(sp3 )-H/N-H Cross-Coupling for N-Mannich Bases with Hydrogen Evolution.
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DOI: 10.1002/cssc.201802676
Abstract: N-Mannich bases are an important structure in various functional molecules. A new protocol to synthesize N-Mannich bases was established through electrochemical external-oxidant-free C(sp3 )-H/N-H cross-coupling with hydrogen evolution. Various N-methylanilines were explored in this transformation.… read more here.
Keywords: cross coupling; hydrogen evolution; sp3 cross; mannich bases ... See more keywords
Recent Progress in Decarboxylative Oxidative Cross‐Coupling for Biaryl Synthesis
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DOI: 10.1002/ejoc.201700121
Abstract: The beginning of the 21st century has seen tremendous growth in the field of decarboxylative activation. Benzoic acid derivatives are now recognised as atom‐economic alternatives to traditional cross‐coupling partners, and they also benefit from being… read more here.
Keywords: decarboxylative oxidative; oxidative cross; cross; benzoic acid ... See more keywords
Copper-Catalyzed Carbonylative Cross-Coupling of Arylboronic Acids with N-Chloroamines for the Synthesis of Aryl Amides
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DOI: 10.1002/ejoc.201700352
Abstract: A novel copper-catalyzed carbonylative cross-coupling between N-chloroamines and arylboronics acids has been developed. With copper(I) oxide as the catalyst, various desired amide compounds were produced in moderate to good yields. Functional groups such as iodide… read more here.
Keywords: carbonylative cross; copper; cross coupling; catalyzed carbonylative ... See more keywords
Oxidative Cross‐Coupling of Substituted Phenols with Unactivated Aromatics
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DOI: 10.1002/ejoc.201700666
Abstract: A regioselective C–H arylation of substituted phenols or naphthols with substituted aromatics in the presence of K2S2O8 and Bu4N+·HSO4– in CF3COOH at ambient temperature providing unsymmetrical biaryls is described. The cross-coupling reaction is compatible with… read more here.
Keywords: radical intermediate; substituted phenols; reaction; cross coupling ... See more keywords