FROM DSM TO DNA: CROSS-DISORDER GENETICS AND THE IMPLICATIONS OF PLEIOTROPY
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.06.147
Abstract: Abstract As large-scale genomic research has begun to sketch the genetic architecture of mental illness, there is increasing evidence that genetic influences transcend the clinically-defined boundaries of psychiatric disorders. Collaborative efforts, including the Psychiatric Genomics… read more here.
Keywords: genetics; cross disorder; psychopathology; implications pleiotropy ... See more keywords
Overlap in genetic risk for cross-disorder vulnerability to mental disorders and genetic risk for altered subcortical brain volumes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.12.062
Abstract: BACKGROUND There have been considerable recent advances in understanding the genetic architecture of psychiatric disorders as well as the underlying neurocircuitry. However, there is little work on the concordance of genetic variations that increase risk… read more here.
Keywords: subcortical brain; risk; cross disorder; genetic risk ... See more keywords
A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008185
Abstract: Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric disease risk can… read more here.
Keywords: prs phewas; cross disorder; psychiatric disorders; disorder ... See more keywords