Zinc Promoted Cross‐Electrophile Sulfonylation to Access Alkyl–Alkyl Sulfones
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406228
Abstract: The transition metal‐catalyzed multi‐component cross‐electrophile sulfonylation, which incorporates SO2 as a linker within organic frameworks, has proven to be a powerful, efficient, and cost‐effective means of synthesizing challenging alkyl–alkyl sulfones. Transition metal catalysts play a… read more here.
Keywords: cross electrophile; alkyl; alkyl sulfones; electrophile sulfonylation ... See more keywords
Photoredox cross-electrophile coupling in DNA-encoded chemistry.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.028
Abstract: A catalytic manifold that enables photoredox cross-electrophile coupling of alkyl bromides with DNA-tagged aryl iodides in aqueous solution is presented. This metallaphotoredox transformation was aided by the identification of a new pyridyl bis(carboxamidine) ligand, which… read more here.
Keywords: photoredox cross; cross electrophile; dna; chemistry ... See more keywords
Zirconium-Redox-Shuttled Cross-Electrophile Coupling of Aromatic and Heteroaromatic Halides.
Sign Up to like & getrecommendations! Published in 2021 at "Chem"
DOI: 10.1016/j.chempr.2021.06.007
Abstract: Transition metal-catalyzed cross-electrophile coupling (XEC) is a powerful tool for forging C(sp2)-C(sp2) bonds in biaryl molecules from abundant aromatic halides. While syntheses of unsymmetrical biaryl compounds through multimetallic XEC is of high synthetic value, selective… read more here.
Keywords: transition metal; electrophile coupling; cross; cross electrophile ... See more keywords
Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis
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DOI: 10.1021/acs.chemrev.4c00524
Abstract: Cross-electrophile coupling (XEC), defined by us as the cross-coupling of two different σ-electrophiles that is driven by catalyst reduction, has seen rapid progression in recent years. As such, this review aims to summarize the field… read more here.
Keywords: cross electrophile; principles methods; coupling principles; electrophile coupling ... See more keywords
Nickel-Catalyzed C(sp3)-C(sp3) Cross-Electrophile Coupling of In Situ Generated NHP Esters with Unactivated Alkyl Bromides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00805
Abstract: The formation of C(sp3)-C(sp3) bonds by cross-coupling remains a challenge in synthesis. Here, we demonstrate a two-step, one-pot protocol for the in situ generation of N-hydroxyphthalimide esters and their nickel-catalyzed cross-electrophile coupling with unactivated alkyl… read more here.
Keywords: unactivated alkyl; nickel catalyzed; sp3; sp3 sp3 ... See more keywords
Nickel-Catalyzed, Manganese-Assisted Denitrogenative Cross-Electrophile-Coupling of Benzotriazinones with Alkyl Halides for ortho-Alkylated Benzamides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02182
Abstract: A nickel-catalyzed denitrogenative cross-electrophile-coupling of benzotriazinones with unactivated alkyl halides (X = Cl, Br, I) in the presence of manganese powder as a reductant has been developed. The reaction furnishes ortho-alkylated secondary benzamides in modest… read more here.
Keywords: ortho alkylated; denitrogenative cross; nickel catalyzed; electrophile coupling ... See more keywords
Synthesis of Vicinal Carbocycles by Intramolecular Nickel-Catalyzed Conjunctive Cross-Electrophile Coupling Reaction
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c02481
Abstract: A nickel-catalyzed intramolecular conjunctive cross-electrophile coupling reaction has been established. This method enables the synthesis of 3,5-vicinal carbocyclic rings found in numerous biologically active compounds and natural products. We provide mechanistic experiments that indicate this… read more here.
Keywords: reaction; nickel catalyzed; conjunctive cross; coupling reaction ... See more keywords
Nickel-Catalyzed Diastereoselective Cross-Electrophile Ring Opening of 7-Oxabenzonorbornadienes with Aromatic Aldehydes.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00471
Abstract: In this protocol, we developed a nickel-catalyzed diastereoselective cross-electrophile ring opening reaction of 7-oxabenzonorbornadienes with aromatic aldehydes as the electrophilic coupling partner utilizing Zn as the stoichiometric reductant. In this reaction, a challenging stereoselective bond… read more here.
Keywords: electrophile ring; nickel catalyzed; catalyzed diastereoselective; diastereoselective cross ... See more keywords
Electrochemical Nickel-Catalyzed Cross-Electrophile Coupling of Alkenyl Triflates with α-Chloroamides.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c02072
Abstract: Cross-electrophile coupling reactions of different electrophiles have been extensively studied but mainly limited to bromides and iodides. Here, we report an electrochemically induced nickel-catalyzed cross-electrophile coupling strategy between alkenyl triflates and α-chloroamides in an undivided… read more here.
Keywords: cross electrophile; nickel catalyzed; catalyzed cross; electrophile coupling ... See more keywords
One-Pot Sequential Alcohol Activation and Nickel-Catalyzed Cross-Electrophile Coupling with Chlorosilanes
Sign Up to like & getrecommendations! Published in 2025 at "Organic Letters"
DOI: 10.1021/acs.orglett.5c00830
Abstract: A formal deoxygenative silylation of primary alcohols is reported. The one-pot procedure consists of an in situ bromination of the alcohol and a subsequent nickel-catalyzed cross-electrophile coupling of the formed alkyl bromide and various vinyl-substituted… read more here.
Keywords: cross electrophile; catalyzed cross; one pot; electrophile coupling ... See more keywords
Nickel-Catalyzed Desymmetrizing Cross-Electrophile Coupling of Cyclic Meso-Anhydrides.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00114
Abstract: A Ni-catalyzed desymmetrizing cross-electrophile coupling of cyclic meso-anhydrides with aryl triflates has been successfully demonstrated. This is the only example using cyclic meso-anhydrides in cross-electrophile coupling reactions. A diverse array of valuable γ-keto acid building… read more here.
Keywords: cross electrophile; catalyzed desymmetrizing; meso anhydrides; cyclic meso ... See more keywords