Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.03.002
Abstract: Re-emerging human adenoviruses type 14 (HAdV14) and 55 (HAdV55) represent two highly virulent adenoviruses. The neutralizing antibody (nAb) responses elicited by infection or immunization remain largely unknown. Herein, we generated hexon-chimeric HAdV14 viruses harboring each… read more here.
Keywords: hadv14 hadv55; neutralizing antibody; antibody; fiber ... See more keywords
Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45163
Abstract: More than 50% of HIV-1 infection globally is caused by subtype_C viruses. Majority of the broadly neutralizing antibodies (bnAbs) targeting HIV-1 have been isolated from non-subtype_C infected donors. Mapping the epitope specificities of bnAbs provides… read more here.
Keywords: phage; hiv; cross; cross neutralizing ... See more keywords
Cross-neutralizing CRF01_AE-infected Plasma from Malaysia Targets CD4-binding Site of Human Immunodeficiency Virus Type-1 (HIV-1) Envelope Glycoprotein.
Sign Up to like & getrecommendations! Published in 2021 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2020.0299
Abstract: HIV-1 antigenic variation poses a great challenge for vaccine immunogen design to elicit broadly neutralizing antibodies (bNAb). Over the last 10-15 years great progress has been made to understand the conserved sites of sensitivity on… read more here.
Keywords: hiv envelope; crf01 infected; hiv; cross ... See more keywords
HIV Coinfection Provides Insights for the Design of Vaccine Cocktails to Elicit Broadly Neutralizing Antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00324-22
Abstract: Despite being the focus of extensive research, we still do not know how to reproducibly elicit cross-neutralizing antibodies against variable pathogens by vaccination. Here, we characterize the antibody responses in people coinfected with more than… read more here.
Keywords: neutralizing antibodies; broadly neutralizing; neutralizing antibody; antibody responses ... See more keywords
Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0222436
Abstract: Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines that protect against influenza across multiple years. However, efficient… read more here.
Keywords: generation; neutralizing antibodies; cross neutralizing; stem ... See more keywords
Longitudinal analysis of SARS-CoV-2 reinfection reveals distinct kinetics and emergence of cross-neutralizing antibodies to variants of concern
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1148255
Abstract: The ongoing evolution of SARS-CoV-2 continues to raise new questions regarding the duration of immunity to reinfection with emerging variants. To address these knowledge gaps, controlled investigations in established animal models are needed to assess… read more here.
Keywords: neutralizing antibodies; infection; reinfection; sars cov ... See more keywords