Organocatalyzed Cross-Nucleophile Couplings: Umpolung of Catalytic Enamines.
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DOI: 10.1021/acs.accounts.2c00149
Abstract: ConspectusThe concept of umpolung, or polarity reversal, introduced by Seebach and Corey nearly half a century ago, ushered a new paradigm into synthetic chemistry. Novel connections were able to be forged among functional groups that… read more here.
Keywords: reaction; nucleophile couplings; organocatalyzed cross; cross nucleophile ... See more keywords
λ3-Iodane/Lewis Acid Mediated Intramolecular Cross-Nucleophile Coupling of β-Amino Acrylates: Chemodivergent Syntheses of Indole Alkaloidal Frameworks.
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DOI: 10.1021/acs.orglett.2c02060
Abstract: Herein, we report an unprecedented intramolecular cross-nucleophile coupling strategy of indole tethered β-amino acrylates using a catalyst system combining λ3-iodanes and Lewis acids to achieve the chemodivergent synthesis of three unique alkaloid skeletons. It was… read more here.
Keywords: nucleophile coupling; cross nucleophile; intramolecular cross; amino acrylates ... See more keywords