Discovery and Mediation Analysis of Cross-Phenotype Associations With Asthma and Body Mass Index in 12q13.2.
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DOI: 10.1093/aje/kwaa144
Abstract: Twin studies suggest that shared genetics contributes to the comorbidity of asthma and obesity, but candidate-gene studies provide limited evidence of pleiotropy. We conducted genome-wide association analyses of asthma and body mass index (BMI) among… read more here.
Keywords: cross phenotype; bmi; body mass; asthma body ... See more keywords
Statistical Analysis of Multiple Phenotypes in Genetic Epidemiologic Studies: From Cross-Phenotype Associations to Pleiotropy
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DOI: 10.1093/aje/kwx296
Abstract: In the context of genetics, pleiotropy refers to the phenomenon in which a single genetic locus affects more than 1 trait or disease. Genetic epidemiologic studies have identified loci associated with multiple phenotypes, and these… read more here.
Keywords: phenotype associations; analysis; epidemiologic studies; cross phenotype ... See more keywords