Cross‐presentation of dead‐cell‐associated antigens by DNGR‐1+ dendritic cells contributes to chronic allograft rejection in mice
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948501
Abstract: The purpose of this study was to elucidate whether DC NK lectin group receptor‐1 (DNGR‐1)‐dependent cross‐presentation of dead‐cell‐associated antigens occurs after transplantation and contributes to CD8+ T cell responses, chronic allograft rejection (CAR), and fibrosis.… read more here.
Keywords: fibrosis; cd8; cross presentation; cell ... See more keywords
Nanovaccine based on a protein-delivering dendrimer for effective antigen cross-presentation and cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.03.037
Abstract: Cancer vaccines for prevention and treatment of tumors have attracted tremendous interests as a type of cancer immunotherapy strategy. A major challenge in achieving robust T-cell responses to destruct tumor cells after vaccination is the… read more here.
Keywords: antigen cross; cross presentation; antigen; cancer immunotherapy ... See more keywords
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.05.021
Abstract: Summary Cross-presentation of antigens from dead tumor cells by type 1 conventional dendritic cells (cDC1s) is thought to underlie priming of anti-cancer CD8+ T cells. cDC1 express high levels of DNGR-1 (a.k.a. CLEC9A), a receptor… read more here.
Keywords: presentation; secreted gelsolin; cross presentation; dngr dependent ... See more keywords
Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.06.038
Abstract: Summary Conventional type 1 DCs (cDC1s) excel at cross-presentation of dead cell-associated antigens partly because they express DNGR-1, a receptor that recognizes exposed actin filaments on dead cells. In vitro polymerized F-actin can be used… read more here.
Keywords: dngr; cell associated; associated antigens; cross presentation ... See more keywords
Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.07.016
Abstract: Cyclic di-nucleotides (CDN) are potent stimulators of innate and adaptive immune responses. Cyclic di-AMP (CDA) is a promising adjuvant that generates humoral and cellular immunity. The strong STING-dependent stimulation of type I IFN represents a… read more here.
Keywords: ifn; cross presentation; type ifn; ifn tnf ... See more keywords
MHC Class I Cross-Presentation: Stage Lights on Sec22b.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in immunology"
DOI: 10.1016/j.it.2017.07.002
Abstract: Efficient (cross-)presentation of antigens internalized by dendritic cells (DCs) requires vesicular communication between the early secretory and the endocytic/phagocytic pathways, in which the Sec22b protein has been suggested to have a key role. Here, we… read more here.
Keywords: presentation stage; cross presentation; cross; class cross ... See more keywords
iTRAQ-based quantitative proteomic analysis reveals Bai-Hu-Tang enhances phagocytosis and cross-presentation against LPS fever in rabbit.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.05.022
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Bai-Hu-Tang (BHT), a classical anti-febrile Chinese formula comprising of liquorice, anemarrhena rhizome, gypsum and rice, has been traditionally used to anti-febrile treatment and promote the production of body fluid to relieve thirst. In… read more here.
Keywords: lps fever; phagocytosis; analysis; group ... See more keywords
The Content of CpG-DNA in Antigen-CpG Conjugate Vaccines Determines Their Cross-Presentation Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00091
Abstract: Cross-presentation, the process that facilitates display of exogenous antigens on MHC-I molecules, is a crucial step in the cascade of CD8 T cell activation. Potentiation of cross-presentation therefore represents an essential design criterion for development… read more here.
Keywords: presentation activity; antigen cpg; cpg; cross presentation ... See more keywords
Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
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DOI: 10.1038/s41467-019-10661-8
Abstract: The magnitude of T cell responses to infection is a function of the naïve T cell repertoire combined with the context and duration of antigen presentation. Using mass spectrometry, we identify and quantify 21 class… read more here.
Keywords: presentation; direct cross; cross presentation; abundance ... See more keywords
Stem cell–immune cell cross-talk
Sign Up to like & getrecommendations! Published in 2018 at "Nature Immunology"
DOI: 10.1038/s41590-018-0282-0
Abstract: Cross-presentation of exogenous particulate antigen is essential for the priming of CD8+ T cells and effective adaptive immunity to viruses and tumors. In Science, Theisen et al. identify a new player, the BEACH domain–containing protein… read more here.
Keywords: immune cell; cross presentation; cross; stem cell ... See more keywords
Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aaz1580
Abstract: Platelet-monocyte “adhesion synapse” initiates physiologic biogenesis of cross-presenting dendritic cells. Dendritic cells (DCs) are adept at cross-presentation and initiation of antigen-specific immunity. Clinically, however, DCs produced by in vitro differentiation of monocytes in the presence… read more here.
Keywords: platelet selectin; presentation; cross presentation; differentiation ... See more keywords