Cross-Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β-Hairpin Antimicrobial Amphiphiles.
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DOI: 10.1002/smll.202003899
Abstract: Novel antimicrobial peptides (AMPs) have revolutionarily evolved into formidable candidates for antibiotic substitute materials against pathogenic infections. However, cost, lability, disorderly sequences, systemic toxicology, and biological profiles have plagued the perennial search. Here, a progressive… read more here.
Keywords: strand interaction; sequence pattern; bending sequence; cross strand ... See more keywords
CH-π interaction between cross-strand amino acid pairs stabilizes β-hairpins.
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DOI: 10.1039/d0cc05653g
Abstract: We identified several CH-π donor-acceptor pairs involving amino acid side chains with less polarized C-H bonds at a solvent-exposed site between the strands of a β-hairpin peptide. Therein, we observe a distance-dependent induction of CH-π… read more here.
Keywords: amino acid; interaction cross; cross strand; interaction ... See more keywords