Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.070
Abstract: A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood. Here, we employed an unbiased cross-tissue… read more here.
Keywords: ilc3s; residing ilc3s; cross tissue; organ residing ... See more keywords
Partitioning and aggregating cross-tissue and tissue-specific genetic effects to identify gene-trait associations
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49924-4
Abstract: TWAS have shown great promise in extending GWAS loci to a functional understanding of disease mechanisms. In an effort to fully unleash the TWAS and GWAS information, we propose MTWAS, a statistical framework that partitions… read more here.
Keywords: cross tissue; tissue specific; tissue tissue; genetic effects ... See more keywords
Cross-tissue multicellular coordination and its rewiring in cancer
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-025-09053-4
Abstract: The multicellular coordination that underlies tissue homeostasis and disease progression is of fundamental interest1, 2, 3, 4–5. However, how diverse cell types are organized within tissue niches for cohesive functioning remains largely unknown. Here we… read more here.
Keywords: cancer; cross tissue; multicellular coordination; cellular modules ... See more keywords
A statistical framework for cross-tissue transcriptome-wide association analysis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Genetics"
DOI: 10.1038/s41588-019-0345-7
Abstract: Transcriptome-wide association analysis is a powerful approach to studying the genetic architecture of complex traits. A key component of this approach is to build a model to impute gene expression levels from genotypes by using… read more here.
Keywords: cross tissue; tissue; association; transcriptome wide ... See more keywords
A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-80122-w
Abstract: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder with environmental factors being the primary risk determinants. However, genetic factors also substantially contribute to the susceptibility and progression of COPD. Although genome-wide association studies… read more here.
Keywords: susceptibility; copd; cross tissue; wide association ... See more keywords
A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-89246-z
Abstract: Age-related macular degeneration (AMD) is a complex multifactorial disease with a significant genetic component. Despite extensive research efforts, the underlying molecular mechanisms remain elusive, necessitating innovative approaches to identify specific genes involved in the pathogenesis… read more here.
Keywords: susceptibility genes; cross tissue; amd; study ... See more keywords
Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbx068
Abstract: Closely linking genetics and environment factors, epigenetics has been of increasing interest in psychiatric disease studies. In this work, we integrated single nucleotide polymorphisms (SNPs), DNA methylation of blood and saliva, and brain gray matter… read more here.
Keywords: methylation; cross tissue; gray matter; brain ... See more keywords
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abl4290
Abstract: Understanding gene function and regulation in homeostasis and disease requires knowledge of the cellular and tissue contexts in which genes are expressed. Here, we applied four single-nucleus RNA sequencing methods to eight diverse, archived, frozen… read more here.
Keywords: cell; single nucleus; disease; cross tissue ... See more keywords
Cross-tissue coordination between SLC nucleoside transporters regulates reproduction in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011425
Abstract: Metabolism is fundamental to organism physiology and pathology. From the intricate network of metabolic reactions, diverse chemical molecules, collectively termed metabolites, are produced. In multicellular organisms, metabolite communication between different tissues is vital for maintaining… read more here.
Keywords: slc; physiology; cross tissue; caenorhabditis elegans ... See more keywords
A Perspective of the Cross-Tissue Interplay of Genetics, Epigenetics, and Transcriptomics, and Their Relation to Brain Based Phenotypes in Schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00343
Abstract: Genetic association studies of psychiatric disorders have provided unprecedented insight into disease risk profiles with high confidence. Yet, the next research challenge is how to translate this rich information into mechanisms of disease, and further… read more here.
Keywords: epigenetics transcriptomics; genetics epigenetics; cross tissue; genetics ... See more keywords
A cross-tissue transcriptome association study identifies key genes in essential hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1114174
Abstract: Genome-wide association study (GWAS) have identified over 1,000 loci associated with blood pressure. However, these loci only explain 6% of heritability. Transcriptome-wide association studies (TWAS) combine GWAS summary data with expression quantitative trait loci (eQTL)… read more here.
Keywords: hypertension; key genes; association study; essential hypertension ... See more keywords