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   Articles with "cross trait" as a keyword



A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-58248-w

Abstract: Lung and gastrointestinal diseases often occur together, leading to more adverse health outcomes than when a disease of one of these systems occurs alone. However, the potential genetic mechanisms underlying lung-gastrointestinal comorbidities remain unclear. Here,… read more here.

Keywords: lung; gastrointestinal diseases; analysis; lung gastrointestinal ... See more keywords

Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis

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recommendations! Published in 2024 at "Schizophrenia Bulletin"

DOI: 10.1093/schbul/sbae087

Abstract: Abstract Background and Hypothesis Schizophrenia (SCZ) and anorexia nervosa (AN) are 2 severe and highly heterogeneous disorders showing substantial familial co-aggregation. Genetic factors play a significant role in both disorders, but the shared genetic etiology… read more here.

Keywords: schizophrenia; etiology; genome wide; shared genetic ... See more keywords

Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI‐EBI Catalog of published genome‐wide association studies

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recommendations! Published in 2019 at "Obesity Reviews"

DOI: 10.1111/obr.12806

Abstract: We conducted a hypothesis‐free cross‐trait analysis for waist‐to‐hip ratio adjusted for body mass index (WHRadjBMI) loci derived through genome‐wide association studies (GWAS). Summary statistics from published GWAS were used to capture all WHRadjBMI single‐nucleotide polymorphisms… read more here.

Keywords: genome wide; cross trait; snps; association ... See more keywords

Shared Genetic Architecture and Causal Relationship Between Asthma and Cardiovascular Diseases: A Large-Scale Cross-Trait Analysis

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2021.775591

Abstract: Background: Accumulating evidence has suggested that there is a positive association between asthma and cardiovascular diseases (CVDs), implying a common architecture between them. However, the shared genetic architecture and causality of asthma and CVDs remain… read more here.

Keywords: cross trait; shared genetic; causal relationship; relationship asthma ... See more keywords