A pH-responsive crosslinker platform for antibody-drug conjugate (ADC) targeting delivery.
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DOI: 10.1039/d2cc03052g
Abstract: We report a new 1-6 self-immolative, traceless crosslinker derived from the natural product gallic acid. The linker acts through a pH-dependent mechanism for drug release. This 5-(hydroxymethyl)pyrogallol orthoester derivative (HMPO) was stable for 24 hours… read more here.
Keywords: crosslinker platform; responsive crosslinker; platform antibody; drug ... See more keywords