Multicrossover Randomized Controlled Trial Designs in Alzheimer Disease
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DOI: 10.1002/ana.25280
Abstract: Conventional parallel group randomized controlled clinical trials (RCT) in Alzheimer's disease (AD) are too large, long, expensive and insensitive to clinical change to meet the urgent need for an effective treatment. While providing good evidence… read more here.
Keywords: alzheimer disease; parallel group; randomized controlled; crossover ... See more keywords
Pharmacokinetic and Safety Comparison of 2 Afatinib Dimaleate Tablets in Healthy Chinese Volunteers Under Fasted Conditions: A Randomized, Open‐Label, 2‐Period, Single‐Dose Crossover Study
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1134
Abstract: In this bioequivalence study, we aimed to evaluate the bioequivalence of test (T) and reference (R) afatinib dimaleate tablets in healthy Chinese subjects under fasted conditions. This was a randomized, open‐label, 2‐period, single‐dose, crossover study.… read more here.
Keywords: period; crossover; afatinib dimaleate; fasted conditions ... See more keywords
Bioequivalence of Two Formulations of Gliclazide in a Randomized Crossover Study in Healthy Caucasian Subjects Under Fasting Conditions
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.445
Abstract: This study aimed to investigate the bioequivalence of 2 formulations of gliclazide modified‐release tablets 60 mg in 48 healthy Caucasian volunteers under fasting conditions. A test product, Gliclazide MR (Ranbaxy Laboratories Limited, now Sun Pharmaceutical… read more here.
Keywords: healthy caucasian; bioequivalence; crossover; fasting conditions ... See more keywords
Effect of Silymarin Treatment on Circulating Bilirubin and Cardiovascular Disease Risk Factors in Healthy Men: A Single‐Blind, Randomized Crossover Trial
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.962
Abstract: This clinical trial (ACTRN12619001296123) investigated the impact of silymarin (Legalon®) on circulating bilirubin concentration, lipid status, systemic inflammation, and antioxidant status. The study design was a randomized, placebo‐controlled, single‐blind crossover trial of healthy men (18‐65… read more here.
Keywords: trial; silymarin; crossover; silymarin treatment ... See more keywords
A pH-Neutral, Aqueous Redox Flow Battery with a 3600-Cycle Lifetime: Micellization-Enabled Ultrastability and Crossover Suppression.
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DOI: 10.1002/cssc.202001286
Abstract: Redox flow batteries (RFBs) are a highly promising large-scale energy storage technology for mitigating the intermittency nature of renewable energy sources. Here, we report the design and implementation of a micellization strategy in an anthraquinone-based,… read more here.
Keywords: cycle; micellization; redox flow; crossover ... See more keywords
On the Role of the Internal Pressure on the Photo-Induced Spin-Crossover behavior of [FexM1-x(phen)2(NCS)2] solid solutions (M=Ni(II), Zn(II) and Cd(II))
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.201700350
Abstract: Abstract: The thermal and light-induced magnetic properties of a family of metal-diluted spin-crossover complexes [FexM1-x (phen)2(NCS)2] (phen = 1,10-phenantholine and M = Ni (II), Cd(II)) is reported and compared to previous results obtained in the… read more here.
Keywords: phen ncs; crossover; spin crossover; pressure photo ... See more keywords
Engineering Solvation Complex-Membrane Interaction to Suppress Cation Crossover in 3 V Cu-Al Battery.
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DOI: 10.1002/smll.202003438
Abstract: Metal-metal batteries such as the 3 V Cu-Al system are highly desirable for large-scale energy storage owing to their low cost and excellent scalability of Cu and Al foils. However, the dissolved Cu cations will… read more here.
Keywords: engineering solvation; crossover; battery; solvation complex ... See more keywords
Lower Bounds on the Runtime of Crossover-Based Algorithms via Decoupling and Family Graphs
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DOI: 10.1007/s00453-020-00776-6
Abstract: The runtime analysis of evolutionary algorithms using crossover as search operator has recently produced remarkable results indicating benefits and drawbacks of crossover and illustrating its working principles. Virtually all these results are restricted to upper… read more here.
Keywords: crossover; family; based algorithms; crossover based ... See more keywords
An experimental analysis of a new two-stage crossover operator for multiobjective optimization
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DOI: 10.1007/s00500-015-1810-6
Abstract: Evolutionary algorithms for multiobjective problems utilize three types of operations for progressing toward the higher fitness regions of the search space. Each type of operator contributes in a different way toward the achievement of the… read more here.
Keywords: two stage; crossover; tsx operator; stage crossover ... See more keywords
Oral morphine drops for prompt relief of breathlessness in patients with advanced cancer—a randomized, double blinded, crossover trial of morphine sulfate oral drops vs. morphine hydrochloride drops with ethanol (red morphine drops)
Sign Up to like & getrecommendations! Published in 2019 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-019-05116-1
Abstract: Purpose Episodic breathlessness is frequent in palliative cancer patients. Opioids are the only pharmacological agents with sufficient evidence in treatment. In Denmark, the main recommendation is red morphine drops (RMD), an off-label solution of morphine,… read more here.
Keywords: breathlessness; trial; morphine; crossover ... See more keywords
A directional crossover (DX) operator for real parameter optimization using genetic algorithm
Sign Up to like & getrecommendations! Published in 2018 at "Applied Intelligence"
DOI: 10.1007/s10489-018-1364-2
Abstract: Nature-inspired optimization algorithms have received more and more attention from the researchers due to their several advantages. Genetic algorithm (GA) is one of such bio-inspired optimization techniques, which has mainly three operators, namely selection, crossover,… read more here.
Keywords: crossover; genetic algorithm; crossover operator; optimization ... See more keywords