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   Articles with "crossover study" as a keyword



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Pharmacokinetics and Bioequivalence of 2 Azithromycin Tablet Formulations: A Randomized, Open‐Label, 2‐Stage Crossover Study in Healthy Volunteers

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recommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1098

Abstract: The current study aimed to assess the bioequivalence of a new branded azithromycin with the reference formulation. An open‐label, randomized, 2‐stage, crossover study design was implemented involving 77 healthy volunteers under fasting conditions. Each volunteer… read more here.

Keywords: reference; crossover study; bioequivalence; open label ... See more keywords
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Comparing the Pharmacokinetics of 2 Novel Intravenous Tramadol Dosing Regimens to Oral Tramadol: A Randomized 3‐Arm Crossover Study

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recommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.746

Abstract: Tramadol is a dual‐mechanism (opiate and monoamine reuptake inhibition) analgesic. Intravenous (IV) tramadol has been widely prescribed outside the United States. However, there have not been studies comparing the pharmacokinetics (PK) of IV dosing regimens… read more here.

Keywords: comparing pharmacokinetics; dosing regimens; crossover study; intravenous tramadol ... See more keywords
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Audiovisual distraction for pain relief in paediatric inpatients: A crossover study

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recommendations! Published in 2017 at "European Journal of Pain"

DOI: 10.1002/ejp.915

Abstract: Pain is a stressful experience that can have a negative impact on child development. The aim of this crossover study was to examine the efficacy of audiovisual distraction for acute pain relief in paediatric inpatients. read more here.

Keywords: paediatric inpatients; audiovisual distraction; relief paediatric; crossover study ... See more keywords
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The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study

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recommendations! Published in 2019 at "American Journal of Cardiovascular Drugs"

DOI: 10.1007/s40256-019-00348-2

Abstract: BackgroundThis was an open-label, phase I, nonrandomized, single-sequence, crossover study to evaluate the effect of concomitant administration of multiple doses of clarithromycin on the single-dose exposure, safety, and tolerability of apixaban in healthy subjects.MethodsIn total,… read more here.

Keywords: sequence crossover; administration; single sequence; clarithromycin ... See more keywords
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What biomechanical factors are more important in compression depth for children lifesavers? A randomized crossover study

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recommendations! Published in 2019 at "American Journal of Emergency Medicine"

DOI: 10.1016/j.ajem.2018.05.003

Abstract: Objective: To evaluate the biomechanical aspects involved in Cardiopulmonary Resuscitation's compression depth by children. Methods: A randomized crossover study with 196 children between 9 and 14 years‐old was conducted. The children performed four CPR hands‐only… read more here.

Keywords: compression; randomized crossover; crossover study; compression depth ... See more keywords
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Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover study.

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recommendations! Published in 2019 at "Chemosphere"

DOI: 10.1016/j.chemosphere.2019.124667

Abstract: Exposure to air pollution can have both short-term and long-term effects on health. However, the relationships between specific pollutants and their effects can be obscured by characteristics of both the pollution and the exposed population.… read more here.

Keywords: health; term; term health; short term ... See more keywords
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An open‐label, randomized, four‐treatment crossover study evaluating the effects of salt form, acetaminophen, and food on the pharmacokinetics of phenylephrine

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recommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"

DOI: 10.1016/j.yrtph.2018.04.008

Abstract: ABSTRACT Phenylephrine hydrochloride (HCl) is a decongestant available in over‐the‐counter (OTC) medicines. Previously marketed prescription products contained phenylephrine tannate, an extended‐release salt, which allowed dosing every 8–12 h. Given the regulatory history that cold medicines… read more here.

Keywords: salt; acetaminophen; crossover study; hcl ... See more keywords
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Evaluation of eLearning for the teaching of undergraduate ophthalmology at medical school: a randomised controlled crossover study

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recommendations! Published in 2018 at "Eye"

DOI: 10.1038/s41433-018-0096-1

Abstract: AimTo compare ophthalmology teaching delivered by eLearning with traditional lectures, in terms of undergraduate performance and satisfaction.MethodsRandomised controlled crossover study at King’s College London Medical School with 245 third year medical students. The ophthalmology syllabus… read more here.

Keywords: satisfaction; medical school; controlled crossover; ophthalmology ... See more keywords
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Effects of digitalized university curriculum-associated teaching on the equilibrium of autonomic neurophysiology and disposition of learners in medical school (EDUCATE-AND-LEARN): protocol for a randomized crossover study

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recommendations! Published in 2021 at "Annals of Medicine"

DOI: 10.1080/07853890.2021.1996626

Abstract: Abstract Background Homoeostasis of the autonomic nervous system (ANS) contributes to cognitive functional integrity in learners and can be greatly influenced by emotions and stress. While moderate stress can enhance learning and memory processes, long-term… read more here.

Keywords: face face; study; crossover study; face ... See more keywords
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Bioavailability of vitamin D biofortified pork meat: results of an acute human crossover study in healthy adults

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recommendations! Published in 2023 at "International Journal of Food Sciences and Nutrition"

DOI: 10.1080/09637486.2023.2182256

Abstract: Abstract Vitamin D intakes are concerningly low. Food-based strategies are urgently warranted to increase vitamin D intakes and subsequently improve 25-hydroxyvitamin D (25(OH)D) concentrations. This acute randomised three-way crossover study investigated the efficacy of vitamin… read more here.

Keywords: crossover study; vitamin biofortified; biofortified pork; pork ... See more keywords
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Substitution of Corn Starch with Resistant Starch Type 4 in a Breakfast Bar Decreases Postprandial Glucose and Insulin Responses: A Randomized, Controlled, Crossover Study

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recommendations! Published in 2018 at "Current Developments in Nutrition"

DOI: 10.1093/cdn/nzy066

Abstract: Abstract Background Resistant starches type 4 (RS4) are chemically modified starches that are resistant to digestion by human enzymes. Objective We aimed to test our hypothesis that replacement of standard starch with RS4 in a… read more here.

Keywords: insulin; crossover study; glucose insulin; breakfast bar ... See more keywords