The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2019.12.002
Abstract: Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated… read more here.
Keywords: crossroad proteostasis; proteostasis; sigma receptor; receptor crossroad ... See more keywords