Glycosylation at the Crossroads of Cancer and Neurodevelopmental Disorders: A Shared Molecular Landscape
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.70341
Abstract: Glycosylation as a central molecular mechanism linking cancer progression to NDDs. Center, the process of glycosylation which affects abnormal glycan expression, gene regulation, and immune system dysfunction. Left, basic features of tumorigenesis: immune escape, cell… read more here.
Keywords: cancer; neurodevelopmental disorders; crossroads cancer; cancer neurodevelopmental ... See more keywords
USP39 at the crossroads of cancer immunity: regulating immune evasion and immunotherapy response through RNA splicing and ubiquitin signaling
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1665775
Abstract: Deubiquitinating enzymes (DUBs) are responsible for the removal of ubiquitin from substrates, thereby antagonizing ubiquitination and regulating a multitude of biological pathways including cell cycle progression, signal transduction, and transcriptional regulation. Ubiquitin Specific Protease-39 (USP39),… read more here.
Keywords: cancer; crossroads cancer; rna splicing; immunotherapy ... See more keywords
14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease
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DOI: 10.3390/ijms20143518
Abstract: 14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds… read more here.
Keywords: cancer aging; age related; aging age; related neurodegenerative ... See more keywords