Large-scale lysine crotonylation analysis reveals its potential role in spermiogenesis in the Chinese mitten crab Eriocheir sinensis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2020.103891
Abstract: Lysine crotonylation (Kcr) is a recently-discovered type of post-translational modification. Although Kcr has been reported in many species, little is known about this process in crustaceans. In this study, pan anti-lysine crotonylation antibody enrichment and… read more here.
Keywords: sinensis; kcr; spermiogenesis; lysine crotonylation ... See more keywords
Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.09.029
Abstract: Metabolic signaling to chromatin often underlies how adaptive transcriptional responses are controlled. While intermediary metabolites serve as co-factors for histone-modifying enzymes during metabolic flux, how these modifications contribute to transcriptional responses is poorly understood. Here,… read more here.
Keywords: crotonylation; gene expression; histone crotonylation;
Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-0924-2
Abstract: Due to the plethora natural products made by Streptomyces, the regulation of its metabolism are of great interest, whereas there is a lack of detailed understanding of the role of posttranslational modifications (PTM) beyond traditional… read more here.
Keywords: metabolism; catabolite repression; carbon catabolite; streptomyces roseosporus ... See more keywords
YWHAE/14-3-3ε crotonylation regulates leucine deprivation-induced autophagy.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2166276
Abstract: Macroautophagy/autophagy is an important process responsible for protein turnover and cell survival in amino acid-deprived conditions, especially for leucine (Leu). With the dramatic advances in mass spectrometry, many new post-translational modifications (PTMs) have been identified.… read more here.
Keywords: deprivation induced; deprivation; ywhae crotonylation; crotonylation ... See more keywords
Comprehensive analysis of lysine crotonylation in proteome of maintenance hemodialysis patients
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000012035
Abstract: Introduction: Histone post-translational modifications (PTMs) carry epigenetic information to regulate diverse cellular processes at the chromatin level. Crotonylation, one of the most important and common PTMs, plays a key role in the regulation of various… read more here.
Keywords: lysine crotonylation; analysis; lysine; crotonylation ... See more keywords
Crotonylation versus acetylation in petunia corollas with reduced acetyl-CoA due to PaACL silencing.
Sign Up to like & getrecommendations! Published in 2022 at "Physiologia plantarum"
DOI: 10.1111/ppl.13794
Abstract: Protein acetylation and crotonylation are important post-translational modifications (PTMs) of lysine. In animal cells, the correlation of acetylation and crotonylation has been well characterized and the lysines of some proteins are acetylated or crotonylated depending… read more here.
Keywords: petunia; acetylation; acetyl coa; paacl silencing ... See more keywords
Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination–mediated DNA repair
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aay4697
Abstract: Large-scale crotonylome reveals CDYL-regulated crotonylation in diverse functions including RPA-mediated HR DNA repair. Previously, we reported that chromodomain Y–like (CDYL) acts as a crotonyl–coenzyme A hydratase and negatively regulates histone crotonylation (Kcr). However, the global… read more here.
Keywords: crotonylome reveals; dna repair; crotonylation; cdyl regulated ... See more keywords
Proteome-wide and lysine crotonylation profiling reveals the importance of crotonylation in chrysanthemum (Dendranthema grandiforum) under low-temperature
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-020-07365-5
Abstract: Background Low-temperature severely affects the growth and development of chrysanthemum which is one kind of ornamental plant well-known and widely used in the world. Lysine crotonylation is a recently identified post-translational modification (PTM) with multiple… read more here.
Keywords: lysine crotonylation; low temperature; crotonylation; proteome wide ... See more keywords
Dynamics and Functional Interplay of Nonhistone Lysine Crotonylome and Ubiquitylome in Vascular Smooth Muscle Cell Phenotypic Remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.783739
Abstract: Background The crotonylation of histones is discovered of late as one of the post-translational modifications (PTMs) that can regulate gene expression. However, the function of crotonylation on nonhistone proteins in vascular smooth muscle cells (VSMCs)… read more here.
Keywords: phenotypic remodeling; crotonylation; vascular smooth; analysis ... See more keywords
Proteome-Wide Identification and Functional Analysis of Lysine Crotonylation in Trichophyton rubrum Conidial and Mycelial Stages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.832668
Abstract: Lysine crotonylation is a newly discovered post-translational modification (PTM) with key roles in various important regulatory pathways. Despite its functional significance, there is limited knowledge about crotonylation in fungi. Trichophyton rubrum is the most common… read more here.
Keywords: trichophyton rubrum; crotonylation; analysis; conidial mycelial ... See more keywords
Involvement of Histone Lysine Crotonylation in the Regulation of Nerve-Injury-Induced Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.885685
Abstract: Histone lysine crotonylation (KCR), a novel epigenetic modification, is important in regulating a broad spectrum of biological processes and various diseases. However, whether KCR is involved in neuropathic pain remains to be elucidated. We found… read more here.
Keywords: histone; histone lysine; nerve; crotonylation ... See more keywords