Cracking Lysine Crotonylation (Kcr): Enlightening a Promising Post‐Translational Modification
Sign Up to like & getrecommendations! Published in 2024 at "Chembiochem"
DOI: 10.1002/cbic.202400639
Abstract: Lysine crotonylation (Kcr) is a recently discovered post‐translational modification (PTM). Both histone and non‐histone Kcr‐proteins have been associated with numerous diseases including cancer, acute kidney injury, HIV latency, and cardiovascular disease. Histone Kcr enhances gene… read more here.
Keywords: crotonylation; kcr; translational modification; crotonylation kcr ... See more keywords
Protein crotonylation in cancer: mechanisms, functions, and therapeutic potential.
Sign Up to like & getrecommendations! Published in 2025 at "Cell biology and toxicology"
DOI: 10.1007/s10565-025-10130-7
Abstract: Lysine crotonylation (Kcr) has recently emerged as a distinctive post-translational modification with unique structural features and regulatory functions. Since its discovery in 2011, more than 10,000 histone and non-histone crotonylation sites have been identified, underscoring… read more here.
Keywords: crotonylation; cancer; biology; crotonylation cancer ... See more keywords
Large-scale lysine crotonylation analysis reveals its potential role in spermiogenesis in the Chinese mitten crab Eriocheir sinensis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2020.103891
Abstract: Lysine crotonylation (Kcr) is a recently-discovered type of post-translational modification. Although Kcr has been reported in many species, little is known about this process in crustaceans. In this study, pan anti-lysine crotonylation antibody enrichment and… read more here.
Keywords: sinensis; kcr; spermiogenesis; lysine crotonylation ... See more keywords
Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.09.029
Abstract: Metabolic signaling to chromatin often underlies how adaptive transcriptional responses are controlled. While intermediary metabolites serve as co-factors for histone-modifying enzymes during metabolic flux, how these modifications contribute to transcriptional responses is poorly understood. Here,… read more here.
Keywords: crotonylation; gene expression; histone crotonylation;
The mechanisms, regulations, and functions of histone lysine crotonylation
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-01830-w
Abstract: Histone lysine crotonylation (Kcr) is a new acylation modification first discovered in 2011, which has important biological significance for gene expression, cell development, and disease treatment. In the past over ten years, numerous signs of… read more here.
Keywords: crotonylation; kcr modification; lysine crotonylation; histone lysine ... See more keywords
P300 regulates histone crotonylation and preimplantation embryo development
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50731-0
Abstract: Histone lysine crotonylation, an evolutionarily conserved modification differing from acetylation, exerts pivotal control over diverse biological processes. Among these are gene transcriptional regulation, spermatogenesis, and cell cycle processes. However, the dynamic changes and functions of… read more here.
Keywords: crotonylation; crotonylation preimplantation; p300; development ... See more keywords
Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51232-w
Abstract: Protein post-translational modifications (PTMs) are crucial for cancer cells to adapt to hypoxia; however, the functional significance of lysine crotonylation (Kcr) in hypoxia remains unclear. Herein we report a quantitative proteomics analysis of global crotonylome… read more here.
Keywords: crotonylation; cancer; hypoxia; downregulation pgk1 ... See more keywords
Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-0924-2
Abstract: Due to the plethora natural products made by Streptomyces, the regulation of its metabolism are of great interest, whereas there is a lack of detailed understanding of the role of posttranslational modifications (PTM) beyond traditional… read more here.
Keywords: metabolism; catabolite repression; carbon catabolite; streptomyces roseosporus ... See more keywords
Chemical proteomic profiling of lysine crotonylation using minimalist bioorthogonal probes in mammalian cells
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Science"
DOI: 10.1039/d4sc06745b
Abstract: Protein lysine crotonylation has been found to be closely related to the occurrence and development of various diseases. Currently, site identification of crotonylation is mainly dependent on antibody enrichment; however, due to the cost, heterogeneity,… read more here.
Keywords: crotonylation; chemical; chemical proteomic; lysine crotonylation ... See more keywords
YWHAE/14-3-3ε crotonylation regulates leucine deprivation-induced autophagy.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2166276
Abstract: Macroautophagy/autophagy is an important process responsible for protein turnover and cell survival in amino acid-deprived conditions, especially for leucine (Leu). With the dramatic advances in mass spectrometry, many new post-translational modifications (PTMs) have been identified.… read more here.
Keywords: deprivation induced; deprivation; ywhae crotonylation; crotonylation ... See more keywords
Protein crotonylation promotes osteogenic differentiation of periodontal ligament stem cells via the PI3K-AKT pathway.
Sign Up to like & getrecommendations! Published in 2024 at "Stem cells"
DOI: 10.1093/stmcls/sxae018
Abstract: Posttranslational modifications are crucial regulatory mechanisms for cellular differentiation and organismal development. Acylation modification is one of the main posttranslational modifications that play a pivotal role in regulating the osteogenic differentiation of mesenchymal stem cells… read more here.
Keywords: differentiation; crotonylation; stem cells; protein crotonylation ... See more keywords