Reduced efficacy of a Src kinase inhibitor in crowded protein solution
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DOI: 10.1038/s41467-021-24349-5
Abstract: The inside of a cell is highly crowded with proteins and other biomolecules. How proteins express their specific functions together with many off-target proteins in crowded cellular environments is largely unknown. Here, we investigate an… read more here.
Keywords: inhibitor; kinase; src kinase; crowded protein ... See more keywords
Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-025-66972-6
Abstract: Understanding protein motion within the cell is crucial for predicting reaction rates and macromolecular transport in the cytoplasm. A key question is how crowded environments affect protein dynamics through hydrodynamic and direct interactions at molecular… read more here.
Keywords: spectroscopy; reveal anomalous; cage; crowded protein ... See more keywords