ATP antagonizes the crowding-induced destabilization of the human eye-lens protein γS-crystallin.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.014
Abstract: In lens, αβγ-crystallins accounting for ∼90% of ocular proteins with concentrations >400 mg/ml need to remain soluble for the whole life-span and their aggregation can lead to cataract. Mysteriously, despite being a metabolically-quiescent organ, lens maintains… read more here.
Keywords: aggregation; crowding induced; crystallin; eye ... See more keywords
Crowding-Induced DNA Translocation Through a Protein Nanopore.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b05249
Abstract: Crowded cellular environment is highly associated with many significant biological processes. However, the effect of molecular crowding on the translocation behavior of DNA through a pore has not been explored. Here, we use nanopore single-molecule… read more here.
Keywords: dna translocation; dna; crowding induced; induced dna ... See more keywords
Crowding-induced morphological changes in synthetic lipid vesicles determined using smFRET
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.958026
Abstract: Lipid vesicles are valuable mesoscale molecular confinement vessels for studying membrane mechanics and lipid-protein interactions, and they have found utility among bio-inspired technologies including drug delivery vehicles. While vesicle morphology can be modified by changing… read more here.
Keywords: lipid vesicles; vesicle morphology; crowding induced; morphological changes ... See more keywords