Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01887-2
Abstract: Treatment of prostate cancer confronts resistance to androgen receptor (AR)-targeted therapies. AR-associated coregulators and chromatin proteins hold a great potential for novel therapy targets. Here, we employed a powerful chromatin-directed proteomics approach termed ChIP-SICAP to… read more here.
Keywords: crpc cells; androgen; prostate cancer; crpc ... See more keywords
Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway
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DOI: 10.1155/2017/2593674
Abstract: The mRNA expression of CAPN2 was upregulated in CRPC cells (DU145 and PC3) than that in non-CRPC cells. Silencing CAPN2 expression could inhibit DU145 and PC3 cells proliferation by cell cycle arrest at G1 phase.… read more here.
Keywords: capn2 expression; crpc cells; cells proliferation; silencing capn2 ... See more keywords
Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/4065580
Abstract: This project attempts to clarify the expression of MUS81 in castration-resistant prostate cancer (CRPC) and the effect on drug sensitivity to Olaparib. We collected clinical surgical samples of patients who were suffering from benign prostatic… read more here.
Keywords: mus81; crpc cells; prostate cancer; expression mus81 ... See more keywords
Abstract 520: Investigation the function and application of spermine in castration-resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-520
Abstract: Introduction & Objectives: Spermine (Spm) is a typical metabolite that is highly concentrated in healthy prostate epithelium maintaining cell growth and functions. Our previous studies found that Spm was significantly decreased in PCa tissue than… read more here.
Keywords: crpc cells; spm; prostate; castration resistant ... See more keywords