Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.02.015
Abstract: Epidemiological evidence indicates that thyroid stimulating hormone (TSH) is positively correlated with abnormal glucose levels. We previously reported that TSH has direct effects on gluconeogenesis. However, the underlying molecular mechanism remains unclear. In this study,… read more here.
Keywords: thyroid stimulating; increases hepatic; hepatic gluconeogenesis; crtc2 ... See more keywords
A novel role of CRTC2 in promoting nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101402
Abstract: Objective Diet-induced obesity is often associated with nonalcoholic fatty liver disease (NAFLD), which instigates severe metabolic disorders, including cirrhosis, hepatocellular carcinoma, and type 2 diabetes. We have shown that hepatic depletion of CREB regulated transcription… read more here.
Keywords: expression; microscopy; liver; fatty liver ... See more keywords
A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27533-9
Abstract: The molecular targets and mechanisms of propolis ameliorating metabolic syndrome are not fully understood. Here, we report that Brazilian green propolis reduces fasting blood glucose levels in obese mice by disrupting the formation of CREB/CRTC2… read more here.
Keywords: metabolic syndrome; obese mice; creb crtc2; transcriptional complex ... See more keywords
The tacrolimus‐induced glucose homeostasis imbalance in terms of the liver: From bench to bedside
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15665
Abstract: Tacrolimus (TAC), the mainstay of maintenance immunosuppressive agents, plays a crucial role in new‐onset diabetes after transplant (NODAT). Previous studies investigating the diabetogenic effects of TAC have focused on the β cells of islets. In… read more here.
Keywords: homeostasis; bench; tac; crtc2 ... See more keywords
CRTC2 promotes paclitaxel resistance by inducing autophagy in ovarian cancer in part via the PI3K-AKT signaling axis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cancer"
DOI: 10.7150/jca.82233
Abstract: Background: Ovarian cancer is the most malignant gynecological disease, which seriously threatens female physical and mental health. Paclitaxel is a first-line chemotherapy drug in the clinical treatment of ovarian cancer, but drug resistance has become… read more here.
Keywords: pi3k akt; crtc2; ovarian cancer; resistance ... See more keywords