Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.009
Abstract: The signaling of prostaglandin D2 (PGD2) through G-protein-coupled receptor (GPCR) CRTH2 is a major pathway in type 2 inflammation. Compelling evidence suggests the therapeutic benefits of blocking CRTH2 signaling in many inflammatory disorders. Currently, a… read more here.
Keywords: crth2; recognition; structures human; reveal ... See more keywords
The Prostaglandin D2 Receptor CRTH2 Contributes to Airway Hyperresponsiveness during Airway Inflammation Induced by Sensitization without an Adjuvant in Mice
Sign Up to like & getrecommendations! Published in 2024 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000537840
Abstract: Abstract Introduction: Prostaglandin D2 (PGD2), which is produced mainly by Th2 cells and mast cells, promotes a type-2 immune response by activating Th2 cells, mast cells, eosinophils, and group 2 innate lymphoid cells (ILC2s) via… read more here.
Keywords: mice; receptor; airway inflammation; mast cells ... See more keywords
Over-expression of CRTH2 indicates eosinophilic inflammation and poor prognosis in recurrent nasal polyps
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1046426
Abstract: Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by recurrent nasal polyp (NP) growth following surgical removal, but the mechanisms are still not clear. This study aimed to investigate the expression of chemoattractant… read more here.
Keywords: crth2; nasal polyps; expression crth2; expression ... See more keywords