Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
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DOI: 10.1038/s42004-020-00367-0
Abstract: Fragment based methods are now widely used to identify starting points in drug discovery and generation of tools for chemical biology. A significant challenge is optimization of these weak binding fragments to hit and lead… read more here.
Keywords: reaction mixtures; rapid optimisation; crude reaction; lead compounds ... See more keywords