Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors.
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DOI: 10.1016/j.bioorg.2018.04.006
Abstract: Cruzain is the major cysteine protease of Trypanosoma cruzi, the etiological agent of Chagas disease. Reversible covalent cruzain inhibitors can block the steps of cell differentiation in the parasite and kill the organism. To this… read more here.
Keywords: affinity; leveraging cruzain; cruzain; cruzain subsite ... See more keywords