Pentachloropseudilin Treatment Impairs Host Cell Invasion by Trypanosoma cruzi
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200349
Abstract: Pentachloropseudilin (PClP) is a reversible and allosteric inhibitor of type 1 myosin. Here, we addressed the impact of PClP treatment of Trypanosoma cruzi and mammalian host cell on the parasite migration, cell adhesion and invasion. We… read more here.
Keywords: cruzi; cell; invasion; treatment ... See more keywords
Trypanosoma Cruzi G and Y Strains' Metacyclic Trypomastigote Sheds Extracellular Vesicles and Trigger Host‐Cell Communication
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.70043
Abstract: Trypanosoma cruzi, a protozoan parasite, spontaneously releases extracellular vesicles (EVs) that facilitate communication with both invertebrate and vertebrate hosts. The results obtained by several groups indicated compositional variations in EVs generated by distinct types of… read more here.
Keywords: extracellular vesicles; host; host cell; trypanosoma cruzi ... See more keywords
Monocyte‐derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF‐β1
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70014
Abstract: Abstract During cell invasion, large Extracellular Vesicle (lEV) release from host cells was dose‐dependently triggered by Trypanosoma cruzi metacyclic trypomastigotes (Mtr). This lEV release was inhibited when IP3‐mediated Ca2+ exit from the ER and further… read more here.
Keywords: release; cell; cruzi; invasion ... See more keywords
Frontline Science: Autophagy is a cell autonomous effector mechanism mediated by NLRP3 to control Trypanosoma cruzi infection
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.hi1118-461r
Abstract: Autophagy and inflammasome activation are cell‐autonomous and cross‐regulated processes involved in host resistance against infections. Our group previously described that NLRP3 inflammasome is required for the control of Trypanosoma cruzi, the causative agent of Chagas… read more here.
Keywords: effector mechanism; control trypanosoma; control; trypanosoma cruzi ... See more keywords
Metabolic Labeling of Surface Neo-sialylglyconjugates Catalyzed by Trypanosoma cruzi trans-Sialidase.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9148-8_10
Abstract: Trypanosoma cruzi, the protozoan agent of Chagas disease, has evolved an innovative metabolic pathway by which protective sialic acid (SA) residues are scavenged from host sialylglycoconjugates and transferred onto parasite surface mucin-like molecules (or surface… read more here.
Keywords: trans sialidase; surface; cruzi; metabolic labeling ... See more keywords
Production of Recombinant Trypanosoma cruzi Antigens in Leishmania tarentolae.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9148-8_8
Abstract: Trypanosomatids are unicellular organisms that colonize a wide diversity of environments and hosts. For instance, Trypanosoma cruzi is a human pathogen responsible for Chagas diseases, while Leishmania tarentolae infects amphibians and became a biotechnological tool… read more here.
Keywords: tarentolae; production recombinant; cruzi; cruzi antigens ... See more keywords
Metabolomics, lipidomics and proteomics profiling of myoblasts infected with Trypanosoma cruzi after treatment with different drugs against Chagas disease
Sign Up to like & getrecommendations! Published in 2019 at "Metabolomics"
DOI: 10.1007/s11306-019-1583-5
Abstract: Chagas disease, the most important parasitic infection in Latin America, is caused by the intracellular protozoan Trypanosoma cruzi. To treat this disease, only two nitroheterocyclic compounds with toxic side effects exist and frequent treatment failures… read more here.
Keywords: disease; drug; cruzi; host ... See more keywords
Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2017.09.017
Abstract: The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs), TcI-TcVI and Tcbat. This article reviews the present… read more here.
Keywords: genetic diversity; something; cruzi; trypanosoma cruzi ... See more keywords
Differential infectivity of two Trypanosoma cruzi strains in placental cells and tissue.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.07.001
Abstract: Congenital Chagas disease, caused by Trypanosoma cruzi (T. cruzi), has become epidemiologically relevant. The probability of congenital transmission depends on the maternal and developing fetal/newborn immune responses, placental factors and importantly, the virulence of the… read more here.
Keywords: differential infectivity; infectivity two; cruzi; trypanosoma cruzi ... See more keywords
Interactions between local renin angiotensin system and nitric oxide in the brain of Trypanosoma cruzi infected rats.
Sign Up to like & getrecommendations! Published in 2019 at "Acta tropica"
DOI: 10.1016/j.actatropica.2019.03.020
Abstract: Chagas' disease (CD) is a zoonosis caused by the protozoan Trypanosoma cruzi. Besides being an important cause of cardiomyopathy, central nervous system (CNS) manifestations have also been reported in CD. Renin-Angiotensin System (RAS) plays a… read more here.
Keywords: system; infection; cruzi; angiotensin ... See more keywords
Host DNA repair response to oxidative damage is modulated by Trypanosoma cruzi in a strain-dependent manner.
Sign Up to like & getrecommendations! Published in 2021 at "Acta tropica"
DOI: 10.1016/j.actatropica.2021.106127
Abstract: The conservation of genomic integrity and stability is essential for cell survival. DNA Damage Responses (DDRs) are considered of paramount importance for all living beings and involve mechanisms of cell cycle regulation and damage-specific DNA… read more here.
Keywords: dna repair; dna; cruzi; host ... See more keywords