Immune response triggered by Trypanosoma cruzi infection strikes adipose tissue homeostasis altering lipid storage, enzyme profile and adipokine expression
Sign Up to like & getrecommendations! Published in 2018 at "Medical Microbiology and Immunology"
DOI: 10.1007/s00430-018-0572-z
Abstract: Adipose tissue is a target of Trypanosoma cruzi infection being a parasite reservoir during the chronic phase in mice and humans. Previously, we reported that acute Trypanosoma cruzi infection in mice is linked to a… read more here.
Keywords: cruzi infection; trypanosoma cruzi; adipose tissue; tissue ... See more keywords
In vitro and in vivo activity of voriconazole and benznidazole combination on trypanosoma cruzi infection models
Sign Up to like & getrecommendations! Published in 2020 at "Acta Tropica"
DOI: 10.1016/j.actatropica.2020.105606
Abstract: Abstract Combination therapy has been proposed as an ideal strategy to reduce drug toxicity and improve treatment efficacy in Chagas disease. Previously, we demonstrated potent in vivo anti-Trypanosoma cruzi activity of voriconazole. In this work,… read more here.
Keywords: combination; trypanosoma cruzi; cruzi infection; vitro vivo ... See more keywords
Sialic acid removal by trans-sialidase modulates MMP-2 activity during Trypanosoma cruzi infection
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.04.005
Abstract: Matrix metalloproteinases (MMPs) not only play a relevant role in homeostatic processes but are also involved in several pathological mechanisms associated with infectious diseases. As their clinical relevance in Chagas disease has recently been highlighted,… read more here.
Keywords: trans sialidase; activity; cruzi infection; mmp activity ... See more keywords
Cytokine modulation, oxidative stress and thymic dysfunctions: Role of age‐related changes in the experimental Trypanosoma cruzi infection: Age‐related thymic dysfunctions and Trypanosoma cruzi infection
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.08.004
Abstract: Abstract Aging is linked with a thymic oxidative damage and some infectious diseases such as Chagas’ disease may aggravate this process. The aim of this study was to evaluate the production of distinct cytokines as… read more here.
Keywords: age related; trypanosoma cruzi; aged infected; infection ... See more keywords
Use of Tc-rCRP as a target for lytic antibody titration after experimental Trypanosoma cruzi infection.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2017.12.003
Abstract: Experimental Chagas disease has been used as a model to identify several host/parasite interaction factors involved in immune responses to Trypanosoma cruzi infection. One of the factors inherent to this parasite is the complement regulatory… read more here.
Keywords: lytic antibody; trypanosoma cruzi; infection; lytic antibodies ... See more keywords
Course of serological tests in treated subjects with chronic Trypanosoma cruzi infection: A systematic review and meta-analysis of individual participant data
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2018.05.019
Abstract: Highlights • This is the first meta-analysis of individual data in chronic Trypanosoma cruzi infection after treatment.• The probability of seroreversion is variable along the course of follow-up.• An interaction was found between age at… read more here.
Keywords: analysis individual; course; cruzi infection; chronic trypanosoma ... See more keywords
Surveillance and genotype characterization of zoonotic trypanosomatidae in Didelphis marsupialis in two endemic sites of rural Panama
Sign Up to like & getrecommendations! Published in 2022 at "International Journal for Parasitology: Parasites and Wildlife"
DOI: 10.1016/j.ijppaw.2021.12.002
Abstract: Didelphis marsupialis has been reported as a competent reservoir for trypanosomatid parasites infections. The aim of this study was to measure Trypanosoma cruzi, T. rangeli, and Leishmania spp. infection rates and to characterize discrete typing… read more here.
Keywords: didelphis marsupialis; marsupialis two; cruzi infection; infection ... See more keywords
Rapidly progressive course of Trypanosoma cruzi infection in mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene.
Sign Up to like & getrecommendations! Published in 2018 at "Microbes and infection"
DOI: 10.1016/j.micinf.2017.09.001
Abstract: Infection with Trypanosoma cruzi causes Chagas disease and results in myocardial inflammation and cardiomyopathy. Downregulated Hexim1 expression, as in Hexim1+/- mice, reduces cardiac inflammation and fibrosis following ischemic stress. We asked whether reduced expression of… read more here.
Keywords: hexim1 mice; hexim1; infection; inflammation ... See more keywords
Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00775
Abstract: Probing multiple proprietary pharmaceutical libraries in parallel via virtual screening allowed rapid expansion of the structure–activity relationship (SAR) around hit compounds with moderate efficacy against Trypanosoma cruzi, the causative agent of Chagas Disease. A potency-improving… read more here.
Keywords: vivo model; cruzi infection; virtual screening; trypanosoma cruzi ... See more keywords
CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45138-7
Abstract: CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as… read more here.
Keywords: cruzi infection; cd43; trypanosoma cruzi; infection ... See more keywords
Autophagy plays a protective role against Trypanosoma cruzi infection in mice
Sign Up to like & getrecommendations! Published in 2019 at "Virulence"
DOI: 10.1080/21505594.2019.1584027
Abstract: ABSTRACT Autophagy is a catabolic pathway required for cellular and organism homeostasis. Autophagy participates in the innate and adaptive immune responses at different levels. Xenophagy is a class of selective autophagy that involves the elimination… read more here.
Keywords: infection mice; trypanosoma cruzi; infection; autophagy ... See more keywords