The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3
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DOI: 10.1038/s41388-020-01601-8
Abstract: Aneuploidy is a hallmark of genomic instability that leads to tumor initiation, progression, and metastasis. CDC20, Bub1, and Bub3 form the mitosis checkpoint complex (MCC) that binds the anaphase-promoting complex or cyclosome (APC/C), a crucial… read more here.
Keywords: spindle assembly; crybg3; lnc crybg3; bub3 ... See more keywords
Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis via Activating the eEF1A1/MDM2/MTBP Axis
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DOI: 10.3390/ijms22063211
Abstract: The occurrence of distant tumor metastases is a major barrier in non-small cell lung cancer (NSCLC) therapy, and seriously affects clinical treatment and patient prognosis. Recently, long non-coding RNAs (lncRNAs) have been demonstrated to be… read more here.
Keywords: crybg3; mdm2; metastasis; lnc crybg3 ... See more keywords