Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles
Sign Up to like & getrecommendations! Published in 2019 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2019.07.019
Abstract: Rotavirus is a well-studied RNA virus that causes severe gastroenteritis in children. During viral entry, the outer layer of the virion is shed, creating a double-layered particle (DLP) that is competent to perform viral transcription… read more here.
Keywords: rotavirus; transcriptionally active; dlps; reveals architectural ... See more keywords
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.11.001
Abstract: The cytoplasmic polyamine maintains cellular homeostasis by chelating toxic metal cations, regulating transcriptional activity, and protecting DNA. ATP13A2 was identified as a lysosomal polyamine exporter responsible for polyamine release into the cytosol, and its dysfunction… read more here.
Keywords: reveals mechanistic; human atp13a2; polyamine; cryo reveals ... See more keywords
Cryo-EM Reveals a Unique BRCA1 Complex in Metastasis
Sign Up to like & getrecommendations! Published in 2018 at "Microscopy and Microanalysis"
DOI: 10.1017/s143192761800658x
Abstract: Currently, there remains a critical need for mapping proteins implicated in the progression of cancer. Visualizing the biological complexes that support metastatic disease allows for a greater understanding of personalized and targeted therapies. The Breast… read more here.
Keywords: unique brca1; microscopy; brca1; cryo reveals ... See more keywords
Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq6353
Abstract: Repair of DNA damage is critical to genomic integrity and frequently disrupted in cancers. USP1, a nucleus-localized deubiquitinase, lies at the interface of multiple DNA repair pathways and is a promising drug target for certain… read more here.
Keywords: binding; inhibition; reveals mechanism; cryo reveals ... See more keywords