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   Articles with "cryo reveals" as a keyword



Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles

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recommendations! Published in 2019 at "Computational and Structural Biotechnology Journal"

DOI: 10.1016/j.csbj.2019.07.019

Abstract: Rotavirus is a well-studied RNA virus that causes severe gastroenteritis in children. During viral entry, the outer layer of the virion is shed, creating a double-layered particle (DLP) that is competent to perform viral transcription… read more here.

Keywords: rotavirus; transcriptionally active; dlps; reveals architectural ... See more keywords
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Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.

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recommendations! Published in 2021 at "Molecular cell"

DOI: 10.1016/j.molcel.2021.11.001

Abstract: The cytoplasmic polyamine maintains cellular homeostasis by chelating toxic metal cations, regulating transcriptional activity, and protecting DNA. ATP13A2 was identified as a lysosomal polyamine exporter responsible for polyamine release into the cytosol, and its dysfunction… read more here.

Keywords: reveals mechanistic; human atp13a2; polyamine; cryo reveals ... See more keywords

Cryo-EM Reveals a Unique BRCA1 Complex in Metastasis

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recommendations! Published in 2018 at "Microscopy and Microanalysis"

DOI: 10.1017/s143192761800658x

Abstract: Currently, there remains a critical need for mapping proteins implicated in the progression of cancer. Visualizing the biological complexes that support metastatic disease allows for a greater understanding of personalized and targeted therapies. The Breast… read more here.

Keywords: unique brca1; microscopy; brca1; cryo reveals ... See more keywords

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abq6353

Abstract: Repair of DNA damage is critical to genomic integrity and frequently disrupted in cancers. USP1, a nucleus-localized deubiquitinase, lies at the interface of multiple DNA repair pathways and is a promising drug target for certain… read more here.

Keywords: binding; inhibition; reveals mechanism; cryo reveals ... See more keywords

Cryo-EM reveals mechanisms of natural RNA multivalency.

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recommendations! Published in 2025 at "Science"

DOI: 10.1126/science.adv3451

Abstract: Homo-oligomerization of biological macromolecules leads to functional assemblies that are critical to understanding various cellular processes. However, RNA quaternary structures have been rarely reported. Comparative genomics analysis has identified RNA families containing hundreds of sequences… read more here.

Keywords: rna; reveals mechanisms; cryo reveals; rna multivalency ... See more keywords