Optimization of a Cryo-EM Structural Model Representation
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DOI: 10.1016/j.bpj.2016.11.1852
Abstract: Electron cryo-microscopy (cryoEM) has been used to resolve atomic resolution biological structures. However, the resulting density maps and models still lack assessment of accuracy and reproducibility. The densities of some residues particularly, the negative charged… read more here.
Keywords: cryo structural; model representation; microscopy; structural model ... See more keywords
Evolving cryo-EM structural approaches for GPCR drug discovery.
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DOI: 10.1016/j.str.2021.04.008
Abstract: G protein-coupled receptors (GPCRs) are the largest class of cell surface drug targets. Advances in stabilization of GPCR:transducer complexes, together with improvements in cryoelectron microscopy (cryo-EM) have recently been applied to structure-assisted drug design for… read more here.
Keywords: cryo structural; evolving cryo; gpcr drug; drug ... See more keywords
Exploiting Cryo-EM Structural Information and All-Atom Simulations To Decrypt the Molecular Mechanism of Splicing Modulators
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00635
Abstract: Splicing modulators (SMs) pladienolides, herboxidienes and spliceostatins exert their antitumor activity by altering the ability of SF3B1 and PHF5A proteins, components of SF3b splicing factor, to recognize distinct intron branching point sequences, thus finely calibrating… read more here.
Keywords: structural information; sf3b1; cryo structural; information ... See more keywords