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   Articles with "cryo structures" as a keyword



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Cryo-EM structures reveal distinct apo conformations of sortilin-related receptor SORLA.

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recommendations! Published in 2022 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2022.01.108

Abstract: Sorting-related receptor with A-type repeats (SORLA) is an important receptor for regulating normal cellular functions via protein sorting. Here, we determined the structures of the full-length SORLA and identified two distinct conformations of apo-SORLA using… read more here.

Keywords: reveal distinct; distinct apo; structures reveal; cryo structures ... See more keywords
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Atomic cryo-EM structures of viruses.

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recommendations! Published in 2017 at "Current opinion in structural biology"

DOI: 10.1016/j.sbi.2017.07.002

Abstract: During the development of single particle cryo-EM in past five decades, icosahedral viruses have led the resolution progress owing to their large mass and high symmetry. Many technical advances in cryo-EM were first established with… read more here.

Keywords: resolution; virology; structures viruses; atomic cryo ... See more keywords
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Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

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recommendations! Published in 2020 at "Cell Research"

DOI: 10.1038/s41422-020-0280-2

Abstract: The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation… read more here.

Keywords: mechanism; ligand binding; cryo structures; receptor ... See more keywords

Cryo-EM structures of ρ1 GABAA receptors with antagonist and agonist drugs

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-025-61932-6

Abstract: The family of ρ-type GABAA receptors includes potential therapeutic targets in several neurological conditions, and features distinctive pharmacology compared to other subtypes. Here we combine structures, recordings and simulations to characterize the binding and conformational… read more here.

Keywords: agonist drugs; structures gabaa; cryo structures; antagonist agonist ... See more keywords

Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R

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recommendations! Published in 2025 at "Nature Chemical Biology"

DOI: 10.1038/s41589-025-01957-6

Abstract: The parathyroid hormone type 1 receptor (PTH1R) is a prototypical class B1 G-protein-coupled receptor that couples to both Gq and Gs, having a crucial role in calcium homeostasis and serving as a therapeutic target for… read more here.

Keywords: receptor; protein coupling; cryo structures; cryo ... See more keywords
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A “Build and Retrieve” methodology to simultaneously solve cryo-EM structures of membrane proteins

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recommendations! Published in 2021 at "Nature methods"

DOI: 10.1038/s41592-020-01021-2

Abstract: Single-particle cryo-electron microscopy (cryo-EM) has become a powerful technique in the field of structural biology. However, the inability to reliably produce pure, homogeneous membrane protein samples hampers the progress of their structural determination. Here, we… read more here.

Keywords: build retrieve; methodology; membrane proteins; cryo structures ... See more keywords

Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes

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recommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1920612117

Abstract: Significance As the terminal electron acceptor of our mitochondrial respiratory chains, complex IV drives and regulates oxidative phosphorylation, the process by which most of our ATP is produced. Complex IV forms supercomplexes (SCs) of different… read more here.

Keywords: iii; structures hypoxic; isoform; revealed cryo ... See more keywords

Cryo-EM structures of alphavirus conformational intermediates in low pH–triggered prefusion states

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2114119119

Abstract: Significance Eastern equine encephalitis virus (EEEV) is a neuroinvasive alphavirus that causes severe neurological diseases. Entry of alphaviruses requires host–virus membrane fusion in endosomes to release the RNA genome into the cytosol for virus replication.… read more here.

Keywords: fusion; membrane fusion; cryo structures; alphavirus conformational ... See more keywords

Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2203660119

Abstract: Significance The enzyme reverse transcriptase (RT) is a key antiviral target, and nonnucleoside RT inhibitors (NNRTIs) are among the frequently used components of antiretroviral therapy for treating HIV-1 infection. The emergence of drug-resistant mutations continues… read more here.

Keywords: cryo structures; dna; m184i; hiv ... See more keywords

Cryo-EM structures of light-harvesting 2 complexes from Rhodopseudomonas palustris reveal the molecular origin of absorption tuning

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2210109119

Abstract: Significance The light-harvesting (LH) complexes of phototrophic bacteria absorb solar energy for photosynthesis, and it is important to understand how the protein components influence the way bound pigments absorb light. We studied the LH2 complexes… read more here.

Keywords: cryo structures; complexes rhodopseudomonas; harvesting complexes; structures light ... See more keywords

Cryo-EM structures reveal the acetylation process of piccolo NuA4

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2414490122

Abstract: Significance Histone acetylation is one of the most important epigenetic modifications that can induce structural changes in chromatin and regulate gene transcription. NuA4 is the only essential acetyltransferase in yeast that can catalyze the acetylation… read more here.

Keywords: reveal acetylation; cryo structures; acetylation process; acetylation ... See more keywords