Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat
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DOI: 10.1002/pro.4396
Abstract: PDZ domains are the most diffused protein–protein interaction modules of the human proteome and are often present in tandem repeats. An example is PDZD2, a protein characterized by the presence of six PDZ domains that… read more here.
Keywords: folding intermediate; pdz; pdz domains; binding properties ... See more keywords
Cryptic binding sites on proteins: definition, detection, and druggability
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DOI: 10.1016/j.cbpa.2018.05.003
Abstract: Many proteins in their unbound structures lack surface pockets appropriately sized for drug binding. Hence, a variety of experimental and computational tools have been developed for the identification of cryptic sites that are not evident… read more here.
Keywords: detection druggability; definition detection; cryptic binding;
Multiple Cryptic Binding Sites are Necessary for Robust Fibronectin Assembly: An In Silico Study
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DOI: 10.1038/s41598-017-18328-4
Abstract: The mechanism of assembly of the extracellular matrix protein fibronectin (FN) into elastic, insoluble fibrils is still poorly understood. FN fibrillogenesis requires cell-generated forces, which expose cryptic FN-FN binding sites buried in FN Type III… read more here.
Keywords: multiple cryptic; cryptic binding; sites necessary; binding ... See more keywords