A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
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DOI: 10.1038/s41467-021-22098-z
Abstract: The RNA-binding protein SFPQ plays an important role in neuronal development and has been associated with several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease. Here, we report that loss… read more here.
Keywords: conserved role; sfpq; role als; last exons ... See more keywords