Readthrough errors purge deleterious cryptic sequences, facilitating the birth of coding sequences.
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DOI: 10.1093/molbev/msaa046
Abstract: De novo protein-coding innovations sometimes emerge from ancestrally non-coding DNA, despite the expectation that translating random sequences is overwhelmingly likely to be deleterious. The "pre-adapting selection" hypothesis claims that emergence is facilitated by prior, low-level… read more here.
Keywords: readthrough errors; selection; non coding; cryptic sequences ... See more keywords