Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
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DOI: 10.1073/pnas.2214556120
Abstract: Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, but in practice… read more here.
Keywords: cryptic transmembrane; secretion; design; designed protein ... See more keywords