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   Articles with "cryptotanshinone" as a keyword



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Cryptotanshinone protects dextran sulfate sodium‐induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation

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recommendations! Published in 2020 at "Phytotherapy Research"

DOI: 10.1002/ptr.6693

Abstract: The incidence of ulcerative colitis (UC) is increasing in recent years. The protective effect of cryptotanshinone, a natural compound from Salvia miltiorrhiza Bunge, on UC was investigated both in vivo and in vitro models. UC… read more here.

Keywords: dextran sulfate; sulfate sodium; intestinal inflammation; cryptotanshinone ... See more keywords
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Anti-tumor and chemosensitization effects of Cryptotanshinone extracted from Salvia miltiorrhiza Bge. on ovarian cancer cells in vitro.

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recommendations! Published in 2017 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2017.04.026

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bge. (Danshen), is a commonly used traditional Chinese medicine to treat high blood pressure in some countries. It has been shown that… read more here.

Keywords: cryptotanshinone; miltiorrhiza bge; ovarian cancer; cancer cells ... See more keywords
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A novel topoisomerase 2a inhibitor, cryptotanshinone, suppresses the growth of PC3 cells without apparent cytotoxicity

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recommendations! Published in 2017 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2017.07.007

Abstract: ABSTRACT DNA topoisomerase 2, which is ubiquitously expressed in eukaryotic cells, is an essential nuclear enzyme that promotes cell survival by regulating DNA topology and chromatid separation. This enzyme has been validated as a target… read more here.

Keywords: topoisomerase inhibitor; novel topoisomerase; cryptotanshinone; topoisomerase ... See more keywords
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Cryptotanshinone enhances wound healing in type 2 diabetes with modulatory effects on inflammation, angiogenesis and extracellular matrix remodelling

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recommendations! Published in 2020 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2020.1803369

Abstract: Abstract Context Cryptotanshinone (CT) is a diterpene quinone compound from Salvia miltiorrhiza Bge. Labiatae has been widely used in cardio-cerebral vascular diseases, which could be potentially effective in treating diabetic wounds. Objective This study evaluates… read more here.

Keywords: wound healing; vegf; extracellular matrix; cryptotanshinone ... See more keywords

Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

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recommendations! Published in 2022 at "Natural Product Communications"

DOI: 10.1177/1934578x221130874

Abstract: Cryptotanshinone is a quinone diterpene extracted from the traditional Chinese medicine Salvia miltiorrhiza root that shows obvious anticancer activity. The aim of this study was to investigate the mechanism of action of cryptotanshinone as an… read more here.

Keywords: salvia miltiorrhiza; cryptotanshinone; gastric cancer; model ... See more keywords
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Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit

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recommendations! Published in 2019 at "Frontiers in Neurology"

DOI: 10.3389/fneur.2019.00381

Abstract: Cryptotanshinone (CTs), an active component isolated from the root of Salvia miltiorrhiza (SM), has been shown to exert potent neuroprotective property. We here established an oxygen-glucose deprivation/recovery (OGD/R)-injured Neurovascular Unit (NVU) model in vitro to… read more here.

Keywords: glucose deprivation; deprivation recovery; cryptotanshinone; oxygen glucose ... See more keywords
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Comparative Proteomics Analysis Reveals the Reversal Effect of Cryptotanshinone on Gefitinib-Resistant Cells in Epidermal Growth Factor Receptor-Mutant Lung Cancer

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.837055

Abstract: Cryptotanshinone (CTS) is a lipophilic constituent of Salvia miltiorrhiza, with a broad-spectrum anticancer activity. We have observed that CTS enhances the efficacy of gefitinib in human lung cancer H1975 cells, yet little is known about… read more here.

Keywords: lung cancer; h1975 cells; cryptotanshinone; differential proteins ... See more keywords
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Anticancer potential of cryptotanshinone on breast cancer treatment; A narrative review

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.979634

Abstract: Breast cancer has recently been known as the first lethal malignancy in women worldwide. Despite the existing treatments that have improved the patients’ prognosis, some types of breast cancer are serious challenges to treat. Therefore,… read more here.

Keywords: cryptotanshinone; breast cancer; cancer treatment; cancer ... See more keywords
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Preparation and optimization of surface stabilized cryptotanshinone nanocrystals with enhanced bioavailability

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recommendations! Published in 2023 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2023.1122071

Abstract: Cryptotanshinone (CTS) is a plant product extracted from Salvia miltiorrhiza Bunge with various pharmacological significances. In addition to its activities against coronary heart disease, hyperlipidemia, stroke, hepatitis and chronic renal failure, it demonstrates antimetastatic effects.… read more here.

Keywords: surface stabilized; bioavailability; cryptotanshinone; optimization surface ... See more keywords
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Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone

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recommendations! Published in 2023 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2023.1127219

Abstract: Introduction: Cryptotanshinone(CTS), a compound derived from the root of Salvia miltiorrhiza, has been linked to various of diseases, particularly pulmonary fibrosis. In the current study, we investigated the benefit of CTS on Sprague-Dawley (SD) rats… read more here.

Keywords: pulmonary fibrosis; cryptotanshinone; tissue distribution; fibrosis ... See more keywords
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Cryptotanshinone Alleviates Oxidative Stress and Reduces the Level of Abnormally Aggregated Protein in Caenorhabditis elegans AD Models

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms231710030

Abstract: Alzheimer’s disease (AD) is one of the leading causes of dementia. As the first common neurodegenerative disease, there are no effective drugs that can reverse the progression. The present study is to report the anti-AD… read more here.

Keywords: abnormally aggregated; oxidative stress; level abnormally; caenorhabditis elegans ... See more keywords