Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts
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DOI: 10.1038/s41598-019-52121-9
Abstract: Designed armadillo repeat proteins (dArmRPs) bind extended peptides in a modular way. The consensus version recognises alternating arginines and lysines, with one dipeptide per repeat. For generating new binding specificities, the rapid and robust analysis… read more here.
Keywords: binding surface; binding proteins; repeat; surface crystal ... See more keywords
Crystals of TELSAM–target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts
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DOI: 10.1098/rsob.210271
Abstract: While conducting pilot studies into the usefulness of fusion to TELSAM polymers as a potential protein crystallization strategy, we observed novel properties in crystals of two TELSAM–target protein fusions, as follows. (i) A TELSAM–target protein… read more here.
Keywords: target protein; telsam target; crystal contacts; target ... See more keywords