Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury
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DOI: 10.1002/advs.202411735
Abstract: During the formation of kidney stones, the interaction between crystals and tubular epithelial cells (TECs) leads to tubular injury and dysfunction, which in turn promote stone formation. However, the molecular mechanisms underlying these changes in… read more here.
Keywords: calcium oxalate; caox crystal; deposition; enhancer ... See more keywords
Sensitivity of snowfall forecast over North China to ice crystal deposition/sublimation parameterizations in the WSM6 cloud microphysics scheme
Sign Up to like & getrecommendations! Published in 2021 at "Quarterly Journal of the Royal Meteorological Society"
DOI: 10.1002/qj.4132
Abstract: Ice‐phase cloud microphysical processes are very complicated, and there are still many uncertainties in current microphysics parameterization schemes. In this study, two alternative ice crystal deposition/sublimation (ICDS) parameterizations, following the Harrington et al., Journal of… read more here.
Keywords: crystal deposition; deposition; wsm6; ice ... See more keywords
Limitations of the Current Standards of Care for Treating Gout and Crystal Deposition in the Primary Care Setting: A Review.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2016.12.011
Abstract: PURPOSE This article outlines several important issues regarding the management of patients with gout. The topics discussed include best practices for gout based on the most current guidelines, opportunities for improving gout management, and current… read more here.
Keywords: crystal deposition; treatment; current standards; gout ... See more keywords
Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt
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DOI: 10.1093/toxsci/kfaa191
Abstract: Abstract Poor solubility of drug candidates mainly affects bioavailability, but poor solubility of drugs and metabolites can also lead to precipitation within tissues, particularly when high doses are tested. RO0728617 is an amphoteric compound bearing… read more here.
Keywords: crystal deposition; drug; compound; solubility ... See more keywords
Monosodium Urate Crystal Deposition and Its Association With Major Cardiovascular Events
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DOI: 10.1111/1756-185x.70080
Abstract: Monosodium urate (MSU) crystal deposition is a pathological hallmark of gout, not only causing joint inflammation but also potentially exerting adverse effects on the cardiovascular sys-tem. Increasing evidence indicates a significant correlation be-tween MSU crystal… read more here.
Keywords: urate crystal; deposition; crystal deposition; cardiovascular events ... See more keywords
Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study
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DOI: 10.1136/rmdopen-2022-002348
Abstract: Background Gout is of unknown reason associated with cardiovascular disease. Ultrasound is sensitive for detecting crystal deposition and plasma calprotectin is a sensitive inflammatory marker. This study explores the associations between crystal deposition, inflammation and… read more here.
Keywords: artery pathology; gout study; carotid artery; pathology ... See more keywords
The Protective Roles of Estrogen Receptor β in Renal Calcium Oxalate Crystal Formation via Reducing the Liver Oxalate Biosynthesis and Renal Oxidative Stress-Mediated Cell Injury
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DOI: 10.1155/2019/5305014
Abstract: Females develop kidney stones less frequently than males do. However, it is unclear if this gender difference is related to altered estrogen/estrogen receptor (ER) signaling. Here, we found that ER beta (ERβ) signals could suppress… read more here.
Keywords: caox crystal; oxalate; crystal deposition; oxalate biosynthesis ... See more keywords
Transcriptional study of hyperoxaluria and calcium oxalate nephrolithiasis in male rats: Inflammatory changes are mainly associated with crystal deposition
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DOI: 10.1371/journal.pone.0185009
Abstract: Hyperoxaluria associated with renal deposition of calcium oxalate (CaOx) crystals causes renal injury and inflammation leading to number of diseases including chronic kidney disease (CKD). It is however, not been possible to separate the renal… read more here.
Keywords: crystal deposition; male rats; deposition; caox crystal ... See more keywords