Do Fragments and Crystallization Additives Bind Similarly to Drug-like Ligands?
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DOI: 10.1021/acs.jcim.6b00769
Abstract: The success of fragment-based drug design (FBDD) hinges upon the optimization of low-molecular-weight compounds (MW < 300 Da) with weak binding affinities to lead compounds with high affinity and selectivity. Usually, structural information from fragment-protein… read more here.
Keywords: information; crystallization additives; binding modes; drug ... See more keywords