Crystallization and characterization of small molecular multidrug resistance inhibitor targeting P-glycoprotein, NSC23925 isomers
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DOI: 10.1016/j.molstruc.2019.05.010
Abstract: Abstract The correlation between P-glycoprotein (Pgp) overexpression and multidrug resistance (MDR) in cancer is well-established. Recently, we identified (2-(4-methoxyphenyl)-4-quinolinyl) (2-piperidinyl)methanol (5) (NSC23925) as the most selective and potent MDR inhibitor. NSC23925 binds to Pgp, thus… read more here.
Keywords: characterization small; multidrug resistance; crystallization characterization; multidrug ... See more keywords