Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties.
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DOI: 10.1016/j.ejmech.2021.113792
Abstract: The lack of an effective treatment makes Alzheimer's disease a serious healthcare problem and a challenge for medicinal chemists. Herein we report interdisciplinary research on novel multifunctional ligands targeting proteins and processes involved in the… read more here.
Keywords: aggregation; buche; crystallography aided; development crystallography ... See more keywords