Interaction of cyclophilin a and human coronavirus 229E N protein is essential for virus replication.
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DOI: 10.1016/j.antiviral.2019.104620
Abstract: The well-known immunosuppressive drug cyclosporin A inhibits replication of various viruses including coronaviruses by binding to cellular cyclophilins thus inactivating their cis-trans peptidyl-prolyl isomerase function. Viral nucleocapsid proteins are inevitable for genome encapsidation and replication.… read more here.
Keywords: protein; cyclophilin; csa derivatives; interaction ... See more keywords