G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13445
Abstract: There are two types of abnormal hematopoiesis in solid tumor occurrence and treatment: pathological hematopoiesis, and myelosuppression induced by radiotherapy and chemotherapy. In this review we primarily focus on the abnormal pathological hematopoietic differentiation in… read more here.
Keywords: csf; csf induced; csf csf; hematopoiesis ... See more keywords
Comparison of plasma and CSF biomarkers in predicting cognitive decline
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51670
Abstract: Concentrations of amyloid‐β peptides (Aβ42/Aβ40) and neurofilament light (NfL) can be measured in plasma or cerebrospinal fluid (CSF) and are associated with Alzheimer’s disease brain pathology and cognitive impairment. This study directly compared plasma and… read more here.
Keywords: plasma csf; cognitive decline; csf; comparison plasma ... See more keywords
Development of the brain ventricular system from a comparative perspective
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DOI: 10.1002/ca.23994
Abstract: The brain ventricular system (BVS) consists of brain ventricles and channels filled with cerebrospinal fluid (CSF). Disturbance of CSF flow has been linked to scoliosis and neurodegenerative diseases, including hydrocephalus. This could be due to… read more here.
Keywords: brain ventricular; csf flow; comparative perspective; csf ... See more keywords
A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1208
Abstract: This open‐label, randomized, 3‐treatment, 3‐period, 6‐sequence, crossover study in healthy subjects compared the pharmacokinetic and pharmacodynamic properties of a lipid‐based (soft gelatin capsule) prototype final market image (pFMI) formulation of tropifexor (90‐µg) to its clinical… read more here.
Keywords: formulation; csf; food; concentration ... See more keywords
A Phase 1 First‐in‐Human Single‐Ascending‐Dose Trial With ESB1609, a Selective Agonist to the Sphingosine‐1‐Phosphate Receptor 5
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1256
Abstract: ESB1609 is a small‐molecule sphingosine‐1‐phosphate‐5 receptor–selective agonist designed to restore lipid homeostasis by promoting cytosolic egress of sphingosine‐1‐phosphate to reduce abnormal levels of ceramide and cholesterol in disease. A phase 1 study was conducted in… read more here.
Keywords: csf; esb1609; phosphate receptor; sphingosine ... See more keywords
Strongyloides in cerebrospinal fluid
Sign Up to like & getrecommendations! Published in 2017 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.23648
Abstract: We report a case of Strongyloides in a patient with advanced HIV-infection. A 45-year-old Latino man with diabetes mellitus type II and recent episode of pneumonia presented to the emergency center after one week of… read more here.
Keywords: infection; csf; strongyloides cerebrospinal; patient ... See more keywords
Basophilic meningitis
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25098
Abstract: We report the case of a 9-year-old girl was admitted to the hospital with fever, headache, and vomiting. Physical examination revealed stiff neck, positive Brudzinski's sign, negative Kerning's sign, and skin rash in lumbar region.… read more here.
Keywords: csf; meningitis; basophilic meningitis; blood ... See more keywords
Elevated granulocyte colony stimulating factor (CSF) causes cerebellar deficits and anxiety in a model of CSF‐1 receptor related leukodystrophy
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DOI: 10.1002/glia.24310
Abstract: Colony stimulating factor (CSF) receptor‐1 (CSF‐1R)‐related leukoencephalopathy (CRL) is an adult‐onset, demyelinating and neurodegenerative disease caused by autosomal dominant mutations in CSF1R, modeled by the Csf1r+/− mouse. The expression of Csf2, encoding granulocyte‐macrophage CSF (GM‐CSF)… read more here.
Keywords: csf; csf3; csf1r mice; stimulating factor ... See more keywords
Predictors for successful PBSC collection on the fourth day of G‐CSF‐induced mobilization in allogeneic stem cell donors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21528
Abstract: Peripheral blood stem cells (PBSCs) used for allogeneic transplantation are collected by apheresis after pre‐treatment of donors with G‐CSF. Using modern apheresis devices stem cells can be collected more efficiently. It was studied whether collection… read more here.
Keywords: csf; stem cell; day; collection ... See more keywords
Increased serum pro‐B‐type natriuretic peptide in hematopoietic progenitor cell donors stimulated with G‐CSF
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21979
Abstract: Hematopoietic stem cells (HPCs) donors mobilized by granulocyte‐colony‐stimulating factor (G‐CSF) can develop various signs and symptoms. proBNP (pro‐B‐type natriuretic peptide) is a serum marker of heart failure. A donor who developed severe adverse reactions after… read more here.
Keywords: natriuretic peptide; csf; serum probnp; serum ... See more keywords
Confirmation of neurometabolic diagnoses using age‐dependent cerebrospinal fluid metabolomic profiles
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12253
Abstract: Timely diagnosis is essential for patients with neurometabolic disorders to enable targeted treatment. Next‐Generation Metabolic Screening (NGMS) allows for simultaneous screening of multiple diseases and yields a holistic view of disturbed metabolic pathways. We applied… read more here.
Keywords: age dependent; age; csf; neurometabolic disorders ... See more keywords