Novel CSF biomarkers to discriminate FTLD and its pathological subtypes
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DOI: 10.1002/acn3.629
Abstract: Frontotemporal lobar degeneration (FTLD) is the second most prevalent dementia in young patients and is characterized by the presence of two main protein aggregates in the brain, tau (FTLD‐Tau) or TDP43 (FTLD‐TDP), which likely require… read more here.
Keywords: csf biomarkers; biomarkers discriminate; novel csf; ftld pathological ... See more keywords
Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies.
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DOI: 10.1007/978-1-4939-7704-8_11
Abstract: Among others, the existence of pathophysiological biomarkers such as cerebrospinal fluid (CSF) Aβ-42, t-tau, and p-tau preceding the onset of Alzheimer's disease (AD) symptomatology have shifted the conceptualization of AD as a continuum. In addition,… read more here.
Keywords: neuroimaging methods; csf biomarkers; analysis csf; csf ... See more keywords
Correlation between CSF biomarkers and COVID-19 meningoencephalitis: A case series
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DOI: 10.1016/j.rmcr.2020.101335
Abstract: Background Recent studies have focused on the incidence rate and pattern of meningoencephalitis in the coronavirus disease 2019 (COVID-19). Aim This study aims to shed more light on the CSF pattern and clinical characteristics of… read more here.
Keywords: csf biomarkers; meningoencephalitis; case; correlation csf ... See more keywords
The use of cerebrospinal fluid biomarkers to measure change in neurodegeneration in Alzheimer’s disease clinical trials
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2017.1341311
Abstract: ABSTRACT Introduction: All recent phase 3 trials of potentially disease-modifying therapies for Alzheimer’s disease (AD) have so far failed. Potential reasons include enrolling subjects whose disease is too advanced or who do not have AD… read more here.
Keywords: csf biomarkers; alzheimer disease; disease; clinical trials ... See more keywords
The role of blood and CSF biomarkers in the evaluation of new treatments against multiple sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2017.1400380
Abstract: ABSTRACT Introduction: Multiple sclerosis (MS) is an immune-mediated chronic neurodegenerative disease of the central nervous system (CNS). Therapeutic interventions with immunomodulatory agents reduce disease activity and disability development, which are monitored clinically and by magnetic… read more here.
Keywords: csf biomarkers; csf; disease activity; multiple sclerosis ... See more keywords
CSF biomarkers for dementia
Sign Up to like & getrecommendations! Published in 2022 at "Practical Neurology"
DOI: 10.1136/practneurol-2021-003310
Abstract: Although cerebrospinal fluid (CSF) biomarker testing is incorporated into some current guidelines for the diagnosis of dementia (such as England's National Institute for Health and Care Excellence (NICE)), it is not widely accessible for most… read more here.
Keywords: csf biomarkers; neurology; csf; biomarkers dementia ... See more keywords
White matter abnormalities and cognition in patients with conflicting diagnoses and CSF profiles
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DOI: 10.1212/wnl.0000000000005353
Abstract: Objective To determine whether white matter changes influence progression of cognitive decline in individuals with clinically diagnosed Alzheimer disease (AD) and differing biomarker profiles. Methods Two hundred thirty-six individuals from the Alzheimer's Disease Neuroimaging Initiative… read more here.
Keywords: csf biomarkers; significantly contributed; decline; cognitive decline ... See more keywords
Dissection of synaptic pathways through the CSF biomarkers for predicting Alzheimer disease
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DOI: 10.1212/wnl.0000000000010131
Abstract: Objective To assess the ability of a combination of synaptic CSF biomarkers to separate Alzheimer disease (AD) and non-AD disorders and to help in the differential diagnosis between neurocognitive diseases. Methods This was a retrospective… read more here.
Keywords: csf biomarkers; dissection synaptic; alzheimer disease; synaptic pathways ... See more keywords
Association of Hippocampal Subfields, CSF Biomarkers, and Cognition in Patients With Parkinson Disease Without Dementia
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DOI: 10.1212/wnl.0000000000011224
Abstract: Objective To examine whether hippocampal volume loss is primarily associated with cognitive status or pathologic β-amyloid 1–42 (Aβ42) levels, this study compared hippocampal subfield volumes between patients with Parkinson disease (PD) with mild cognitive impairment… read more here.
Keywords: hippocampal subfields; csf biomarkers; parkinson disease; patients parkinson ... See more keywords
Editors' Note: CSF Biomarkers in Patients With COVID-19 and Neurologic Symptoms: A Case Series
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DOI: 10.1212/wnl.0000000000012526
Abstract: In “CSF Biomarkers in Patients With COVID-19 and Neurologic Symptoms: A Case Series,” Edén et al. describe CSF results in 6 patients with neurologic symptoms in the setting of COVID-19 infection. Three patients had a… read more here.
Keywords: csf biomarkers; patients covid; covid neurologic; neurologic symptoms ... See more keywords
CSF Biomarkers of Alzheimer Disease in Patients With Concomitant α-Synuclein Pathology
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DOI: 10.1212/wnl.0000000000201202
Abstract: Background and Objectives CSF biomarkers β‐amyloid 1-42 (Aβ42), phosphorylated tau 181 (p-tau181), total tau (t-tau), and neurogranin (Ng) can diagnose Alzheimer disease (AD) in life. However, it is unknown whether CSF concentrations, and thus their… read more here.
Keywords: tau; alzheimer disease; pathology; csf biomarkers ... See more keywords