Differential Effects of Fingolimod and Natalizumab on B Cell Repertoires in Multiple Sclerosis Patients
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00975-7
Abstract: Natalizumab and fingolimod are effective multiple sclerosis (MS) therapies that disrupt lymphocyte migration but have differential effects on B cell maturation and trafficking. We investigated their effects on peripheral blood (PB) and cerebrospinal fluid (CSF)… read more here.
Keywords: cell repertoires; differential effects; treatment; csf cell ... See more keywords
Interleukin-1β-induced IRAK1 ubiquitination is required for TH-GM-CSF cell differentiation in T cell-mediated inflammation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.04.010
Abstract: Accumulating evidence suggests granulocyte macrophage-colony stimulating factor (GM-CSF) can function as an inflammatory mediator, but whether GM-CSF-producing CD4+ T cells (TH-GM-CSF) are a distinct T helper cell subset is lacking. Herein we demonstrate that interleukin… read more here.
Keywords: csf cells; csf cell; csf; differentiation ... See more keywords
Single-cell immune profiling reveals a developmentally distinct CD4+ GM-CSF+ T-cell lineage that induces GI tract GVHD
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006084
Abstract: Key Points scRNAseq identifies two CD4+ GM-CSF+ T-cell subsets in the colon during GVHD that can be distinguished based on expression of IFN-γ. CD4+ GM-CSF+ IFN-γ− T cells constitute an IL-7–responsive, transcriptionally and developmentally distinct… read more here.
Keywords: cd4 csf; cell; csf cell; developmentally distinct ... See more keywords