Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.05.042
Abstract: In the spinal cord, cerebrospinal fluid-contacting neurons (CSF-cNs) are GABAergic interoceptive sensory neurons that detect spinal curvature via a functional coupling with the Reissner fiber. This mechanosensory system has recently been found to be involved… read more here.
Keywords: csf cns; spinal cord; cns; sensory neurons ... See more keywords
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06225-x
Abstract: Defects in cerebrospinal fluid (CSF) flow may contribute to idiopathic scoliosis. However, the mechanisms underlying detection of CSF flow in the central canal of the spinal cord are unknown. Here we demonstrate that CSF flows… read more here.
Keywords: spine curvature; csf cns; csf flow; csf ... See more keywords
The neural stem cell properties of Pkd2l1+ cerebrospinal fluid-contacting neurons in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.992520
Abstract: The neural stem cells (NSCs) in the ventricular-subventricular zone of the adult mammalian spinal cord may be of great benefit for repairing spinal cord injuries. However, the sources of NSCs remain unclear. Previously, we have… read more here.
Keywords: neural stem; fluid contacting; cns; csf cns ... See more keywords
Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.83108
Abstract: Cerebrospinal fluid-contacting neurons (CSF-cNs) are enigmatic mechano- or chemosensory cells lying along the central canal of the spinal cord. Recent studies in zebrafish larvae and lampreys have shown that CSF-cNs control postures and movements via… read more here.
Keywords: locomotion; fluid contacting; cns; csf cns ... See more keywords