Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23464
Abstract: Microglia contribute to pathophysiology at all stages of multiple sclerosis. Colony‐stimulating factor‐1 (CSF1) is crucial for microglial proliferation and activation. In this study we measured the CSF1 levels and studied its cellular expression in the… read more here.
Keywords: mouse spinal; eae; expression; csf1 ... See more keywords
RNAscope CSF1 Chromogenic in situ Hybridization: A Potentially Useful Tool in the Differential Diagnosis of Tenosynovial Giant Cell Tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Human pathology"
DOI: 10.1016/j.humpath.2021.05.010
Abstract: Colony Stimulating Factor-1 (CSF1) up regulation and CSF1/Colony-stimulating factor 1 receptor (CSF1R) signaling pathway is central to the tumorigenesis of tenosynovial giant cell tumors (TGCT) of both localized (LTGCT) and diffuse (DTGCT) types, and has… read more here.
Keywords: giant cell; diagnosis; csf1 mrna; csf1 ... See more keywords
CircRNA_28313/miR-195a/CSF1 axis modulates osteoclast differentiation to affect OVX-induced bone absorption in mice
Sign Up to like & getrecommendations! Published in 2019 at "RNA Biology"
DOI: 10.1080/15476286.2019.1624470
Abstract: ABSTRACT Osteoblastic bone formation and osteoclastic bone resorption dynamically maintain the bone homeostasis; in the present study, we attempt to investigate the mechanism of the excessive activation of osteoclasts inducing the deregulation of bone homeostasis… read more here.
Keywords: osteoclast differentiation; mir 195a; circrna 28313; ovx induced ... See more keywords
Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.07.27.501742
Abstract: Colony stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and thus an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize Csf1 stimulating osteoclastogenesis. We recently identified a… read more here.
Keywords: marrow adipogenic; bone; csf1; csf1 marrow ... See more keywords
Abstract 2020: Identification of abnormal CSF1 transcripts in tenosynovial giant cell tumors and dose-dependent increase in plasma CSF1 levels in response to pexidartinib treatment
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Trials"
DOI: 10.1158/1538-7445.am2020-2020
Abstract: Background: Tenosynovial giant cell tumors (TGCTs) are characterized by rearrangements of the colony-stimulating factor 1 (CSF1) gene. Dysregulated CSF1 may attract CSF1 receptor (CSF1R)-bearing mononuclear cells that form the bulk of the tumor. CSF1R inhibitors… read more here.
Keywords: tenosynovial giant; giant cell; plasma csf1; pexidartinib ... See more keywords
CSF1/CSF1R signaling mediates malignant pleural effusion formation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155300
Abstract: Malignant pleural effusion (MPE) is an incurable common manifestation of many malignancies. Its formation is orchestrated by complex interactions among tumor cells, inflammatory cells, and the vasculature. Tumor-associated macrophages present the dominant inflammatory population of… read more here.
Keywords: csf1r; pleural effusion; malignant pleural; csf1 ... See more keywords
Human placenta-based genome-wide mRNA sequencing to identify TEK/IGF1/CSF1/ANGPT2 as crucial segments in the pathogenesis of pre-eclampsia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.944932
Abstract: Pre-eclampsia is a pregnancy-specific disease commonly occurring in late pregnancy and has always been threatening maternal and fetal lives, yet the etiology and pathogenesis of pre-eclampsia are still uncertain. To depict the overall changes of… read more here.
Keywords: pathogenesis pre; eclampsia; pre eclampsia; csf1 ... See more keywords
Expanding the molecular spectrum of tenosynovial giant cell tumors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1012527
Abstract: Background While great advances in clinical and pathological description of tenosynovial giant cell tumors (TGCT) have been made, TGCT molecular heterogeneity represents an ongoing challenge. The canonical oncogenic fusion CSF1::COL6A3 is not systematically observed, suggesting… read more here.
Keywords: giant cell; tenosynovial giant; cell tumors; csf1 ... See more keywords
Molecular Profiling of Atypical Tenosynovial Giant Cell Tumors Reveals Novel Non-CSF1 Fusions
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DOI: 10.3390/cancers12010100
Abstract: Tenosynovial giant cell tumor (TGCT) is a benign neoplasm characterized by recurrent fusions involving the colony-stimulating factor 1 (CSF1) gene and translocation partners including collagen type VI alpha 3 chain (COL6A3) or S100 calcium-binding protein… read more here.
Keywords: tenosynovial giant; giant cell; novel non; csf1 ... See more keywords
Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071852
Abstract: Simple Summary In cancer, regulatory regions of the genome are hijacked by the tumor cells for the activation of oncogenes that lead to cancer initiation and progression. One of the most salient regulatory elements of… read more here.
Keywords: cancer; triple negative; csf1; breast cancer ... See more keywords