Targeting the CSF1/CSF1R Axis is a Potential Treatment Strategy for Malignant Meningiomas.
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DOI: 10.1093/neuonc/noab075
Abstract: BACKGROUND Malignant meningiomas are fatal and lack effective therapy. As M2 macrophages are the most prevalent immune cell type in human meningiomas, we hypothesized that normalizing this immunosuppressive population would be an effective treatment strategy.… read more here.
Keywords: treatment; meningiomas; malignant meningiomas; csf1 csf1r ... See more keywords
CSF1/CSF1R Axis Blockade Limits Mesothelioma and Enhances Efficiency of Anti-PDL1 Immunotherapy
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DOI: 10.3390/cancers13112546
Abstract: Simple Summary CSF1/CSF1R signaling mediates tumor-associated macrophages recruitment and M2 polarization. M2 TAMs are dominant immune populations infiltrating mesothelioma tumors. We evaluated the role of CSF1/CSF1R axis blockade in tumor-infiltrating immune subsets. We also examined… read more here.
Keywords: mesothelioma; anti pdl1; csf1 csf1r; csf1r ... See more keywords