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   Articles with "csf1r" as a keyword



Sustained, complete response to pexidartinib in a patient with CSF1R‐mutated Erdheim–Chester disease

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recommendations! Published in 2022 at "American Journal of Hematology"

DOI: 10.1002/ajh.26441

Abstract: Erdheim–Chester disease (ECD) is a histiocytic neoplasm that predominantly harbors mitogen‐activated protein kinase (MAPK) pathway variants. MAPK inhibitors typically are effective treatments, but mutations outside the MAPK pathway, such as CSF1R variants, may cause refractory… read more here.

Keywords: erdheim chester; csf1r; patient; chester disease ... See more keywords

Evaluation of Soluble Colony Stimulating Factor 1 Receptor (CSF1R) in Peripheral Blood as a Diagnostic Marker of CSF1R‐Related Disorder (CSF1R‐RD) in a Murine Model and CSF1R‐RD Patients

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recommendations! Published in 2024 at "Annals of Neurology"

DOI: 10.1002/ana.27147

Abstract: Mutations in colony stimulating factor 1 receptor (CSF1R) result in CSF1R‐related disorder (CSF1R‐RD). Our previous study demonstrated a proteolytic generation of a soluble CSF1R (sCSF1R) that could potentially serve as a diagnostic biomarker of CSF1R‐RD.… read more here.

Keywords: csf1r; stimulating factor; receptor csf1r; csf1r related ... See more keywords

Is Pre‐Symptomatic Immunosuppression Protective in CSF1R‐Related Leukoencephalopathy?

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recommendations! Published in 2021 at "Movement Disorders"

DOI: 10.1002/mds.28515

Abstract: Adult-onset leukoencephalopathy with spheroids and pigmented glia (ALSP) is the collective disease referring to patients previously diagnosed with hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) or pigmented orthochromatic leukodystrophy (POLD). ALSP is a white matter… read more here.

Keywords: csf1r; pre symptomatic; disease; related leukoencephalopathy ... See more keywords
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Differential regulation of TREM2 and CSF1R in CNS macrophages in an SIV/macaque model of HIV CNS disease

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recommendations! Published in 2020 at "Journal of NeuroVirology"

DOI: 10.1007/s13365-020-00844-1

Abstract: HIV-associated neuroinflammation is primarily driven by CNS macrophages including microglia. Regulation of these immune responses, however, remains to be characterized in detail. Using the SIV/macaque model of HIV, we evaluated CNS expression of triggering receptor… read more here.

Keywords: trem2; csf1r; hiv; disease ... See more keywords
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PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma.

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recommendations! Published in 2020 at "Bone"

DOI: 10.1016/j.bone.2020.115353

Abstract: Osteosarcoma (OSA) is a heterogeneous and aggressive solid tumor of the bone. We recently identified the colony stimulating factor 1 receptor (Csf1r) gene as a novel driver of osteosarcomagenesis in mice using the Sleeping Beauty… read more here.

Keywords: tumor; plx3397 treatment; csf1r; csf1r csf1 ... See more keywords

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.

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recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.10.005

Abstract: Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects. Here, we have identified the mechanism that limited… read more here.

Keywords: csf1r; infiltration tumors; associated fibroblasts; effect ... See more keywords

To Kill a Microglia: A Case for CSF1R Inhibitors.

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recommendations! Published in 2020 at "Trends in immunology"

DOI: 10.1016/j.it.2020.07.001

Abstract: Microglia, the brain's immune sentinels, have garnered much attention in recent years. Researchers have begun to identify the manifold roles that these cells play in the central nervous system (CNS), and this work has been… read more here.

Keywords: csf1r; case csf1r; microglia case; csf1r inhibitors ... See more keywords
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Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.

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recommendations! Published in 2021 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c01006

Abstract: Colony-stimulating factor-1 receptor (CSF1R) is implicated in tumor-associated macrophage (TAM) repolarization and has emerged as a promising target for cancer immunotherapy. Herein, we describe the discovery of orally active and selective CSF1R inhibitors by property-driven… read more here.

Keywords: selective csf1r; murine colon; csf1r; orally active ... See more keywords

Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form

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recommendations! Published in 2023 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.3c00428

Abstract: Colony-stimulating factor-1 receptor (CSF1R) is a receptor tyrosine kinase that controls the differentiation and maintenance of most tissue-resident macrophages, and the inhibition of CSF1R has been suggested as a possible therapy for a range of… read more here.

Keywords: csf1r; selective pyrrolo; synthesis development; autoinhibited form ... See more keywords

Identification of Selective Imidazopyridine CSF1R Inhibitors.

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recommendations! Published in 2024 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.4c00110

Abstract: Colony stimulating factor-1 receptor (CSF1R or c-FMS), a class III receptor tyrosine kinase expressed on members of the mononuclear phagocyte system (MPS), plays a key role in the proper functioning of macrophages, microglia, and related… read more here.

Keywords: csf1r; chemistry; csf1r inhibitors; identification selective ... See more keywords

Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer.

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recommendations! Published in 2024 at "Journal of leukocyte biology"

DOI: 10.1093/jleuko/qiae077

Abstract: Macrophage and osteoclast proliferation, differentiation and survival are regulated by colony-stimulating factor-1 receptor (CSF1R) signaling. Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of osteoclasts and deficiency in bone resorption.… read more here.

Keywords: csf1r; type bone; bone marrow; osteal macrophages ... See more keywords